NAPHTHALIMIDE-MODIFIED CHITOSAN MATERIALS TO CREATE BIODEGRADABLE FILMS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究计划涉及使用萘酰亚胺改性壳聚糖膜的免缝合组织修复方法的开发。这些薄膜是使用专有的光化学交联技术形成的。它们的使用，沿着使用类似技术的相关粘合剂配方，可以提供一种新型的生物相容性，可生物降解的胶带，可用于在许多组织修复手术中取代缝线。使用预先确定的组织模型，学生将评估如何化学和合成改性的薄膜改变物理特性，如溶解度，拉伸强度和寿命。这些信息可用于设计具有特定寿命的薄膜，以满足各种临床应用的需求。可以设计更持久的膜用于实质性组织缺损或重建手术，并且可以使用寿命短的膜来帮助修复较小的组织缺损。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project involves the development of a sutureless tissue repair method using naphthalimide-modified chitosan films. These films are formed using a proprietary crosslinking photochemical technology. Their use, along with a related adhesive formulation using similar technology, could provide a novel biocompatible, biodegradable tape that may be used to replace suture in a number of tissue repair procedures. Using a predetermined tissue model, the student would evaluate how chemical and synthetic modifications to the films alter physical properties such as solubility, tensile strength, and longevity. This information could then be used to design films with specific lifetimes suited to the needs of various clinical applications. Longer lasting films could be designed for use on substantial tissue defects or reconstructive surgery and short-lived films could be used to aid in the repair of minor