Arizona Clinical and Translational Science Award Planning Grant

描述(由申请人提供)：通过明确的临床和教育目标、独特的系统医学重点和全州范围内实施分子知情治疗决策计划的无与伦比的组合，亚利桑那州临床和翻译科学奖将为临床和翻译科学打造一个独特的、变革性的、新颖的和综合的学术家园。亚利桑那州目前的人口是整个美国的一个缩影：不断增长的老龄化人口，大量易患特定疾病的未参保人口，以及聚集但地理上分散的人口。我们建议组织我们的CTSA计划，以便新的临床和转换计划以及教育和职业发展计划将成功地解决这些复杂的健康问题。CTSA计划提供了一个逻辑框架，以整合巴特尔纪念研究所为亚利桑那州的生物医学研究制定全州路线图的国家认可的努力，并利用亚利桑那州各地以研究为导向的生物医学和临床组织在研究和临床专业知识方面的互补优势，包括大学和研究机构、医院和医疗机构、NIDDK和IMS。全州庞大的患者基础是临床、转化和结果研究应用的巨大资源，这些研究将来自我们全州的临床研究努力。我们组建了一支临床医生和科学家队伍，他们代表着最高质量的临床护理和研究，对转化性研究的持续承诺，以及作为团队共同工作的明确承诺。亚利桑那州CTSA团队有其要解决的具体目标，并将通过跨应用、临床和结果研究的连续统工作来实现这一目标，以确保项目具有互补的优势，允许将新发现转化和实施到临床治疗和筛查程序中。认识到我们团队在地理上的分散性，我们已经开发了有效的沟通方法，并将使用基于网络的多中心远程医疗的新一代技术来加强规划期间的沟通，以便所有研究人员和机构能够为产生的联合研究努力做出重大贡献。CTSA代表了具有独特和显著协作记录的机构的综合努力，正式联手改善亚利桑那州和整个医学界的患者结果。

DESCRIPTION (provided by applicant): Through the inimitable combination of defined clinical and educational goals, a unique systems-medicine focus and a statewide commitment to implement a program for molecularly-informed therapeutic decisions, the Arizona Clinical and Translational Science Award will forge a uniquely transformative, novel and integrative academic home for clinical and translational science. Arizona's current population is a microcosm of the US as a whole: a growing aging population, large uninsured populations with predisposition to specific diseases and a clustered but geographically-dispersed populous. We propose to organize our CTSA program so that novel clinical and translational programs and education and career development programs will successfully tackle these complex health problems. The CTSA program provides a logical framework to integrate nationally-recognized efforts by the Battelle Memorial Institute to develop a statewide roadmap for Arizona's biomedical research and capitalizes on the complementary strengths in research and clinical expertise of research-oriented biomedical and clinical organizations across Arizona, including universities and research institutes, hospitals and healthcare institutions, the NIDDK and the IMS. A large statewide patient base is a tremendous resource for application of clinical, translational and outcomes research that will derive from our statewide clinical research efforts. We have assembled a cadre of clinicians and scientists who represent highest quality clinical care and research, an ongoing commitment to translational research and an unequivocal commitment to work together as a team. The Arizona CTSA team has specific goals it will address and will do so by working across the continuum of applied, clinical, and outcomes research ensuring that projects have complementary strengths that will allow translation and implementation of new findings to clinical therapies and screening procedures. Recognizing the geographic dispersment of our team, we have developed effective methods of communication and will use new generation technology for web-based multi-center telemedicine to strengthen communication during the planning period so that all investigators and institutions can contribute significantly to the generated joint research efforts. The CTSA represents the integrated efforts of institutions with a unique and remarkably collaborative track record, formally joining forces to improve outcomes for patients across Arizona and the entire medical community.