INFLUENCE OF BEHAVIORAL EXPERIENCE ON NEURAL PLASTICITY IN STROKE NEUROREHAB

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。琼斯和夏勒特在这个项目中的主要任务是：(A)设计和实施带有控制程序的运动康复计划，以改善单侧感觉运动皮质局灶性缺血损伤大鼠的神经和功能结果；(B)在德克萨斯大学对功能结果进行视频测量分析，包括前肢伸展和感觉运动功能；(C)培训麦克尼尔实验室和南加州大学的其他人员进行康复训练和功能结果测试；(D)准备送往McNeill进行分子变化分析的实验大鼠的大脑；(E)评估双半球新皮质神经元的结构变化，包括来自南加州大学和南加州大学的实验动物大脑中锥体神经元的树突分枝和脊椎变化；(F)参与频繁前往南加州大学并通过电子邮件通信进行实验，研究运动疗法和可增强或降低大鼠和脑缺血损伤患者神经可塑性的制剂的相互作用。主要感兴趣的问题是(1)与单独的手法相比，杂技经验和REACH训练的结合是否会显著改善行为结果，以及(2)对于改善行为功能最优的康复训练手法是否促进了最大的皮质和纹状体神经可塑性变化

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary tasks of Jones and Schallert in this project are to: (a) design and implement a motor rehabilitation program with control procedures to enhance neural and functional outcome in rats that sustain focal ischemic injury unilaterally in the sensorimotor cortex; (b) carry out at UT a videometric analysis of functional outcome, including forelimb reaching and sensorimotor function; (c) train personnel in the McNeill lab and others at USC on rehabilitative training and functional outcome tests; (d) prepare the brains of experimental rats to be sent to McNeill for analyses of molecular changes (e) assess bi-hemispheric neocortical neuronal structural changes, including pyramidal neuron dendritic arborization and spine changes in the brains of experimental animals from both UT and USC; (f) participate by frequent trips to USC and email correspondence in the execution of experiments examining the interactive effects of motor therapy and agents that enhance or reduce neuroplasticity in both rats and people with ischemic injury. The questions of primary interests are (1) whether the combination of acrobatic experience and reach training will significantly improve behavioral outcome compared to either independent manipulation and (2) whether the rehabilitative training manipulation that is optimal for improving behavioral function promotes the greatest cortical and striatal neuroplastic change