CHARACTERIZATION OF LUNG SURFACTANT LIPID DEGRADATION IN PSEUDOMONAS AERUGINOSA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。铜绿假单胞菌（Pseudomonas aeruginosa）是一种机会性病原体，可导致伤口、烧伤，特别是囊性纤维化患者肺部的危及生命的感染，由于耐药机制和生物膜的形成，这种细菌很难用抗生素根除。囊性纤维化患者铜绿假单胞菌肺部感染的发病机制尚不清楚。更好地了解铜绿假单胞菌在肺部的发病机制和生长机制可能会导致发现新的方法来根除这些慢性肺部感染的有机体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pseudomonas aeruginosa, an opportunistic pathogen which causes life-threatening infections in wounds, burns and in particular the lung of cystic fibrosis patients, is a bacterium which is extremely difficult to eradicate with antibiotics due to resistance mechanisms and biofilm formation. The pathogenesis of P. aeruginosa lung infection in cystic fibrosis patients is not clear. A better understanding of the pathogenesis and mechanisms of growth of P. aeruginosa in the lung may lead to identification of new ways to eradicate the organism in these chronic lung infections.