COBRE: LSU HSC: ADMINISTRATIVE CORE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。行政核心设在药学系，并支持该计划的整体管理。行政核心为项目的有效运作提供了保障。项目主任Stephen M. Lanier博士负责项目的所有行政方面和指导工作的监督。Lynnette Small担任COBRE拨款的行政协调员，并与药理学业务经理Karen Jorgenson的部门密切合作。斯莫尔女士建立了一个卓越的办公室，为COBRE行政核心处理所有财务、采购和组织问题。她每月与每位初级调查员和核心主任会面，每周与项目主任拉尼尔博士会面。斯莫尔女士还与我们的部门人事总监林保罗先生密切合作，以引进新员工。三位老教师作为COBRE的新导师加入了我们。Parthasarathy博士从Emory大学加入我们，Lucchesi博士从阿拉巴马大学伯明翰分校加入我们。Kapusta博士是药理学教授，两次获得R01资助，专注于阿片肽在心血管和肾功能控制中的作用。Drs。Lucchesi和Parthasarathy得到了美国国立卫生研究院的多项资助，他们在血管生物学和/或心脏肥厚领域工作。项目，主任和导师如下：项目1 -血管系统中的PARP1和氧化应激项目主任/指导JI: Hamid A. Boulares博士导师：Sampath Parthasarathy博士项目2 -基因转移，氧化应激和糖尿病血管疾病项目主任/指导JI: Frank Park博士导师：Daniel R. Kapusta博士项目3 - VSMC中生长因子和整合素信号的整合项目主任/指导JI: Andrew D. Catling博士导师：Pamela A. Lucchesi博士项目4 -心肌细胞和VSMC信号蛋白的ER到高尔基转运项目主任/导师：吴光宇博士导师：William Claycomb博士和Stephen M. Lanier博士项目5 -一氧化氮缺乏血管平滑肌可塑性项目主任/导师：Gregory M. Dick博士导师：William M. Chilian博士和Daniel R. Kapusta博士项目6 -炎症在内皮再灌注损伤中的作用项目主任/导师JI: Cuihua Zhang博士导师：William M. Chilian博士行政支持团队协助开发了2005年3月提交的两项共享仪器拨款，以及2004年9月提交的NIH机构博士前培训拨款，用于“综合药理和生理科学培训”。这些举措将直接有利于心血管生物学的发展计划。NIH/NCRR共享仪器资助“Thermo Finnigan蛋白质组X LTQ工作站（LC/MS）与IBM电子服务器计算机”PI: Art L. Haas博士项目时间：2006年4月1日- 2007年3月31日总费用：496,150美元提交：2005年3月21日NIH/NCRR共享仪器资助“体内电子顺磁共振成像系统（Bruker Elesys）”PI: Barry Potter博士项目时间：2006年4月1日- 2007年3月31日总费用：482,170美元提交：2005年3月21日NIH/NIGMS博士前培训基金“综合药理和生理科学培训”项目负责人：Stephen M. Lanier博士项目时间：2005年7月1日至2010年6月30日总费用：865,353美元行政核心还为LSUHSC心血管卓越中心和COBRE项目“心血管生物学指导”建立了网站。http://www.medschool.lsuhsc.edu/cardio_center/ http://www.medschool。suhsc.edu/cardio_center/COBRE.asp在即将到来的一年里，我们将继续支持初级调查员的拨款发展，共享仪器奖以及基础设施发展和动物护理设施升级的拨款。这个核心运行良好，预计在接下来的一年里不会有任何变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The administrative core is based in the Department of Pharmacology and supports the overall management of the program. The administrative core provides the umbrella for effective operation of the program. The Program Director, Stephen M. Lanier, Ph.D. is responsible for all administrative aspects of the program and oversight of the mentoring effort. Lynnette Small serves as Administrative Coordinator for the COBRE grant and works very closely with the Department of Pharmacology Business Manager, Karen Jorgenson. Ms. Small has established a superb office that handles all fiscal, purchasing, and organizational issues for the COBRE administrative core. She meets monthly with each of the Junior Investigators and Core Directors and weekly with the Program Director, Dr. Lanier. Ms. Small has also worked very closely with our departmental Personnel Director, Mr. Paul Lam, to bring on new staff. Three established faculty joined us as new mentors on the COBRE. Dr. Parthasarathy joined us from Emory University and Dr. Lucchesi joined us from the University of Alabama - Birmingham. Dr. Kapusta is a Professor in the Department of Pharmacology with two R01 grants focused on the role of opioid peptides on control of cardiovascular and renal function. Drs. Lucchesi and Parthasarathy are well funded by multiple grants from NIH and work in the area of vascular biology and/or cardiac hypertrophy. Projects, Directors and Mentors are listed below: Project 1 - PARP1 and Oxidant Stress in the Vasculature Project Director/Mentored JI: Hamid A. Boulares, Ph.D. Mentor: Sampath Parthasarathy, Ph.D. Project 2 - Gene Transfer, Oxidant Stress, and Diabetic Vascular Disease Project Director/Mentored JI: Frank Park, Ph.D. Mentor: Daniel R. Kapusta, Ph.D. Project 3 - Integration of Growth Factors and Integrin Signaling in VSMC Project Director/Mentored JI: Andrew D. Catling, Ph.D. Mentor: Pamela A. Lucchesi, Ph.D. Project 4 - ER to GOLGI Trafficking of Signaling Proteins in Cardiac Myocytes and VSMC Project Director/Mentored JI: Guangyu Wu, Ph.D. Mentors: William Claycomb, Ph.D. and Stephen M. Lanier, Ph.D. Project 5 - Vascular smooth muscle plasticity in nitric oxide deficiency Project Director/Mentored JI: Gregory M. Dick, Ph.D. Mentors: William M. Chilian, Ph.D. and Daniel R. Kapusta, Ph.D. Project 6 - Role of Inflammation in Endothelial Reperfusion Injury Project Director/Mentored JI: Cuihua Zhang, Ph.D. Mentor: William M. Chilian, Ph.D. The administrative support team assisted in the development of two shared instrumentation grants submitted in March 2005, as well as an NIH institutional predoctoral training grant, submitted in September 2004, for "Training in Integrative Pharmacological and Physiological Sciences". These initiatives will directly benefit the developing program in cardiovascular biology. NIH/NCRR Shared Instrumentation Grant "Thermo Finnigan Proteome X LTQ Workstation (LC/MS) with IBM e-server computer" PI: Art L. Haas, Ph.D. Project Period: 04/01/2006 - 03/31/2007 Total Cost: $496,150 Submitted: March 21, 2005 NIH/NCRR Shared Instrumentation Grant "In Vivo Electron Paramagnetic Resonance Imaging System (Bruker Elesys)" PI: Barry Potter, Ph.D. Project Period: 04/01/2006 - 03/31/2007 Total Cost: $482,170 Submitted: March 21, 2005 NIH/NIGMS Predoctoral Training Grant "Training in Integrative Pharmacological and Physiological Sciences" PI: Stephen M. Lanier, Ph.D. Project Period: 07/01/2005 to 06/30/2010 Total Costs: $865,353 The administrative core also established the WEB site for the LSUHSC Cardiovascular Center of Excellence and for the COBRE program "Mentoring in Cardiovascular Biology". http://www.medschool.lsuhsc.edu/cardio_center/ http://www.medschool. suhsc.edu/cardio_center/COBRE.asp In the upcoming year, we will be providing continued support for grant development by Junior Investigators, Shared Instrumentation Awards and grants for infrastructure development and upgrade of animal care facilities. This core is functioning fine and no changes are anticipated in the upcoming year.