Role of Mu Opioid Receptor in Immune Function

描述（由申请人提供）：这是NIDA赞助的K02独立科学家奖的续期申请。Sabita Roy博士拥有堪萨斯大学劳伦斯分校的博士学位，是明尼苏达大学药学系的教授。她目前由两项独立基金资助；来自NIDA/ nih的DA 12104用于研究吗啡对免疫细胞的影响，来自NIDA/ nih的DA 11806用于研究mu阿片受体在应激诱导免疫调节中的作用。该奖项将为候选人提供释放时间，以扩展其研究技能，提高其科学调查和指导能力。该候选人的长期研究目标是探索吗啡诱导的免疫抑制和增加机会性感染（如肺炎链球菌和HIV/AIDS）易感性的分子和细胞机制。该候选药物已经通过小鼠肺炎链球菌模型证明，吗啡治疗显著增加死亡率和发病率，并加速疾病进展。目前申请的主要目标是培训与药物滥用有关的艾滋病毒/艾滋病研究，并将这方面的研究纳入她正在进行的研究项目。艾滋病毒研究方面的培训将使候选人能够在未来的研究中确定滥用药物调节艾滋病毒复制和/或潜伏期的机制，以及继发性机会感染是否会改变这些过程。为了实现这一目标，将利用释放时间进行小型休假，并在著名的艾滋病毒/艾滋病研究人员的实验室进行艾滋病毒/艾滋病研究方面的培训。“二级奖状”可减轻相当多的教学及行政工作。这个计划得到了药学系和明尼苏达大学的全力支持。

DESCRIPTION (provided by applicant): This is an application for a renewal of a NIDA sponsored K02 Independent Scientist Award. The candidate, Dr. Sabita Roy holds a Ph.D. degree from the University of Kansas, Lawrence and is a Professor in the Department of Pharmacology, University of Minnesota. She is currently funded by two independent grants; DA 12104 from NIDA/NIH-to study the effect of morphine on immune cells and DA 11806 from NIDA/NIH-to investigate the role mu opioid receptor on stress induced immunomodulation. This award will provide the candidate with release time to expand her research skills and enhance her ability for scientific investigations and mentoring. The long-term research goal of the candidate is to explore the molecular and cellular mechanism involved in morphine induced immunosupression and increased susceptibility to opportunistic infections such as S. pneumonia and HIV/AIDS. The candidate has already demonstrated using a murine model of S. pneumonia that morphine treatment significantly increases mortality and morbidity and accelerates disease progression. The major goal of the current application is to train in HIV/AIDS research as it relates to drug abuse and incorporate this line of research into her ongoing research projects. The training in HIV research will allow the candidate in future research to identify mechanisms by which drugs of abuse modulate HIV replication and or latency and if secondary opportunistic infection alter these processes. To achieve this goal release time will be utilized for mini sabbaticals and undertake training in HIV/AIDS research in the labs of eminent HIV/AIDS researchers. The KO 2 Award will facilitate this by relieving considerable amount of teaching and administrative duties. This plan has the full support of the Department of Pharmacology and the University of Minnesota.