Physical Activity and Hip Fractures in Men

描述(申请人提供)：大多数关于预防骨质疏松症的研究都来自老年妇女。女性的患病率远远高于男性，这是因为女性的体重较低，寿命较长，更年期性激素急剧下降。然而，骨质疏松症是男性日益关注的问题，因为他们现在通常活到75岁以上，此时髋部骨折的发病率开始呈指数级上升。体力活动被认为是预防骨质疏松症的一个重要组成部分，然而，在女性身上检查的因素通常适用于男性，而没有足够的研究来确定它们可能因性别而有所不同。即使在女性中，骨骼健康所需的活动的持续时间、强度和生命周期也没有得到充分的定义。根据这一建议，研究人员打算在卫生专业人员随访研究中，在20年的时间里，研究体力活动和不活动与由于轻或中度创伤而导致的髋部骨折风险的关系。活动将根据持续时间和强度进行检查，并将包括步行、中等强度和剧烈活动以及坐着的分析。还将比较早期活动、当前成人活动和终生活动的效果。这些调查人员已经在护士健康研究中使用相同的数据收集工具、确定意外骨折的相同后续程序以及对其他风险因素(包括体重、饮食、吸烟和饮酒)进行相同的两年一次的评估，检查了与髋部骨折风险有关的体力活动。这将允许对活动对髋部骨折风险的影响进行性别比较。显然，需要对骨质疏松症和髋部骨折进行更多的研究，只关注男性。更好地了解体力活动的影响将大大增加目前可用的一般建议。公共卫生相关性：在这项拟议的研究中，我们打算使用先前在卫生专业人员随访队列中收集的数据来检查体力活动和不活动对男性髋部骨折风险的影响。活动因素将包括持续时间、强度和生命周期。以前关于骨质疏松症和髋部骨折的研究大多集中在女性身上，性别差异还没有得到充分的研究。我们打算将我们对男性的研究结果与我们之前对女性活动和髋部骨折的研究结果进行比较。关于专门针对男性的活动的建议，将鼓励扩大有关骨质疏松症的公共卫生信息，使其超越目前的绝经后女性受众，包括日益增长的老年男性人口。

DESCRIPTION (provided by applicant): Most research on the prevention of osteoporosis has been derived from older women. Prevalence is much higher in women than in men due to lower body mass, longer life span, and a precipitous decrease in sex hormones at menopause. However, osteoporosis is a growing concern for men as well as they are now commonly living beyond the age of 75 when hip fracture incidence rates begin to rise exponentially. Physical activity is recognized to be an important component of osteoporosis prevention, yet factors that have been examined in women are typically applied to men without sufficient study to determine how they may differ by gender. Even in women, the duration, intensity, and period of life of activity required for bone health have not been adequately defined. The investigators on this proposal intend to study physical activity and inactivity in relation to the risk of hip fractures due to low or moderate trauma over a twenty-year period in over 46,000 men in the Health Professionals Follow-up Study. Activity will be examined by duration and intensity and will include analyses of walking, moderate and strenuous activities, and sitting. The effects of activity at earlier periods of life, current adult activity, and lifetime activity will also be compared. These same investigators have already examined physical activity in relation to risk of hip fracture in women in the Nurses' Health Study using the same instrument for data collection, the same follow-up procedures for ascertaining incident fractures, and the same biennial assessment of other risk factors, including body weight, diet, smoking, and alcohol consumption. This will allow for gender comparisons of the influence of activity on risk of hip fracture. Clearly, more research is needed on osteoporosis and hip fracture that focuses solely on men. Better knowledge of the effects of physical activity would greatly add to the general advice that is currently available. PUBLIC HEALTH RELEVANCE: In this proposed research, we intend to examine the effects of physical activity and inactivity on risk of hip fractures in men using data previously collected in the Health Professionals Follow-up cohort. Activity factors will include duration, intensity, and period of life. Most of the previous research on osteoporosis and hip fractures has focused on women, and gender differences have not been adequately examined. We intend to compare our results for men with results from our previous research on activity and hip fractures in women. Advice on activity that is specific for men would encourage the expansion of public health messages on osteoporosis to extend beyond the current audience of postmenopausal women to include the growing population of aging men.