Interventions for Body Dysmorphic Disorder

描述（由申请人提供）：项目总结：这是K24面向患者研究的职业中期研究者奖竞争更新申请的第三次也是最后一次提交。这个奖项将为继续指导初级研究人员提供必要的支持，并将大大加强我以患者为导向的研究。我目前的K24奖于2006年8月结束，它为我的指导提供了重要的支持，并使我能够发展新的研究技能。与K24的目的一致，在我目前的奖项期间，我已经写了85篇出版物（81篇已出版或出版，4篇提交），其中许多是由学员共同撰写的。我还获得了额外的联邦资助，为35名学员提供了研究指导，并参加了许多额外的国家和地方指导和领导活动。我是身体畸形障碍（BDD）的少数研究人员之一，这是一种异常严重、相对常见、研究不足的疾病，与自杀意念、自杀企图和自杀未遂的比例明显很高。我的主要职业目标是1)继续以患者为导向的BDD研究（特别是其治疗），2)继续招募和指导以患者为导向研究的初级研究人员。我的研究计划包括目前联邦政府资助的BDD干预研究。奖励期间的新研究将主要集中在开发和测试创新的新疗法。这些研究将包括一项比较药物治疗和认知行为治疗的疗效研究，以及开发一种针对高自杀率患者的联合治疗方法。一些研究将包括翻译成分。我的指导计划将主要关注干预研究，特别是BDD。我在开发和测试药物和社会心理干预方面积累了专业知识，这在干预医生中相对少见，也增强了我的指导能力。我将继续指导个别学员，并参加国家和地方的指导活动。我的指导计划还包括提交一份关于强迫症和BDD的干预和转化（基础临床）研究的T32研究培训资助申请。这个领域的初级调查人员非常有限。续签我的K24奖将为指导提供必要的支持，并使我能够维持我卓有成效的研究计划。与公共卫生的相关性：BDD虽然未得到充分认识，但相对普遍。与大多数其他严重的精神疾病相比，它与更高的自杀率、更差的功能和生活质量有关。继续进行BDD研究，并通过指导培养一批骨干研究人员来继续这项工作，这一点至关重要。我在更广泛的干预研究方面的指导将有助于满足未来研究人员在这一至关重要领域的迫切需求。

DESCRIPTION (provided by applicant): Project Summary: This is the third and final submission of a Competing Renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research. This award will provide essential support for continued mentoring of beginning investigators and will greatly enhance my patient-oriented research. My current K24 award, which ends in 8/06, has provided critical support for my mentoring and has enabled me to develop new research skills. Consistent with the purpose of the K24, during my current award, I have written 85 publications (81 published or in press, and 4 submitted), many of which were co-authored by mentees. I have also obtained additional federal funding, provided research mentoring to 35 mentees, and participated in many additional national and local mentoring and leadership activities. I am one of the very few researchers of body dysmorphic disorder (BDD), an unusually severe, relatively common, and understudied disorder that is associated with markedly high rates of suicidal ideation, suicide attempts, and completed suicide. My primary career goals are to 1) continue patient- oriented research on BDD (in particular, its treatment), and 2) continue to recruit and mentor beginning researchers in patient-oriented research. My research plan includes current federally funded intervention studies for BDD. New research during the award period will focus primarily on developing and testing innovative new treatments. These studies will include an efficacy study comparing pharmacotherapy and CBT, and development of a combined treatment for more highly suicidal patients. Several studies will include translational components. My mentoring plan will focus primarily on interventions research as well as BDD specifically. I have developed expertise in developing and testing both pharmacologic and psychosocial interventions, which is relatively uncommon among interventionists and which enhances my mentoring. I will continue to mentor individual mentees and participate in national and local mentoring activities. My mentoring plan also includes submitting a T32 research training grant application on interventions and translational (basic-clinical) research on OCD and BDD. This area has a very limited pipeline of beginning investigators. Renewal of my K24 award will provide essential support for mentoring and enable me to sustain my fruitful program of research. Relevance to Public Health: BDD, although underrecognized, is relatively common. It is associated with greater suicidality and poorer functioning and quality of life than most other serious mental illnesses. It is critically important to continue BDD research and, through mentoring, develop a cadre of researchers to continue this work. My mentoring on interventions research more broadly will help meet a pressing need for future researchers in this critically important area.