Genetic Mechanisms of Cardiac Disease in the Young

描述（由申请人提供）： 候选人是一名儿科心脏病专家，长期致力于以患者为导向的研究。1995年，他在哈佛医学院的塞德曼实验室接受了为期31个月的博士后研究，并接受了人类分子遗传学家的再培训。2001年1月，他被招募到辛辛那提儿童医院，在儿科心脏病学临床项目和分子心血管生物学心脏发育项目之间建立桥梁。他的长期研究目标是确定小儿心脏病的分子基础。此更新申请旨在为候选人提供支持，以指导儿科心脏病学研究员进行以患者为导向的研究。支持拟议研究的资金由儿科心脏病SCCOR（PI，Benson）和计划项目补助金项目（PI，Gourdie）提供。三个新的以病人为导向的研究项目，特别是支持这项补助金的建议。本研究的目的是根据初步数据所证明的基本原理和可行性来制定的。拟议的计划将为儿科心脏病学研究员提供以患者为导向的研究指导，但为了增加儿科心脏病学的申请人，博士前学生或博士后实习生，博士将被指导。该机构的环境是丰富的心血管研究，和前和博士后水平的培训计划是实质性的。辛辛那提儿童医疗中心有一个完善的以病人为导向的研究项目。有慷慨的机构支持，以建立一个程序的分子遗传学的先天性心脏病。 所有的元素已经组装为建立一个丰富的环境，指导以病人为导向的研究调查人员在年轻的心血管疾病的分子遗传学。在以患者为导向的研究中获得职业中期奖将允许候选人将50%的精力投入到以患者为导向的研究和指导中。

DESCRIPTION (provided by applicant): The Candidate is a pediatric cardiologist with a career long commitment to patient-oriented research. In 1995 he retrained as a human molecular geneticist during a 31-month-long postdoctoral fellowship in the Seidman Laboratory, Harvard Medical School. He was recruited to Cincinnati Children's Hospital in January 2001 to build a bridge between the clinical programs in Pediatric Cardiology and the cardiac development programs in Molecular Cardiovascular Biology. His long-term research objective is to determine the molecular basis of pediatric heart disease. This renewal application is designed to provide the Candidate with support to mentor Fellows in Pediatric Cardiology in patient-oriented research. Funding to support the proposed research is provided by a SCCOR in Pediatric Heart Disease (PI, Benson) and a project on a Program Project Grant (PI, Gourdie). Three new patient-oriented research projects to be specifically supported by this grant are proposed. The aims of the research have been developed based upon the rationale and feasibility demonstrated in preliminary data. The proposed program will provide mentoring in patient-oriented research for Pediatric Cardiology Fellows, but in an effort to increase the applicant pool in Pediatric Cardiology, predoctoral students or postdoctoral trainees with M.D.-Ph.D. will be mentored. The institutional environment is rich in cardiovascular research, and the pre- and postdoctoral level training programs are substantial. A well-established patient-oriented research program exists at the Cincinnati Children's Medical Center. There is generous institutional support to establish a program for molecular genetics of congenital heart disease. All elements have been assembled for building an enriched environment for mentoring patient-oriented research investigators in molecular genetics of cardiovascular disease in the young. Receipt of the Mid-Career Award in patient-oriented research will allow the Candidate to devote 50% effort to research and mentoring in patient-oriented research.