RESEARCH CORE

前列腺癌是美国男性癌症死亡的第二大原因，仅次于皮肤癌。在非洲- 美国男性前列腺癌发病率高65%死亡率高出一倍多 与高加索男人相比。造成这种发病率和死亡率种族差异的原因是什么 非洲裔美国人的疾病知之甚少，但可能涉及生物和环境两个方面 各种因素。克拉克亚特兰大大学癌症研究和治疗开发中心是 建立一个全面的研究计划，以调查涉及到的细胞和遗传因素 前列腺癌的转化，血管生成和转移，以及这些因素在非洲有何不同。 美国男人。这项拨款申请中的三个研究项目将调查1.转化生长因子β信号转导的作用 前列腺癌不同阶段2.雄激素调节免疫/炎症通路的影响 3.蜗牛转录因子和转化生长因子β在前列腺癌骨转移中的作用 前列腺癌细胞。此外，我们建议推行六项试验计划，集中在以下不同方面： 前列腺癌生物学，如：IL-10在前列腺癌免疫中的作用，c-kit配体和信号转导 转移性癌细胞、PI3-激酶亚型在前列腺癌中的作用、染色质重构及其影响 在前列腺癌细胞中，甾醇在前列腺癌细胞增殖和凋亡中的作用，以及在前列腺癌发生、发展中的作用 检测前列腺癌生物标志物的高灵敏度技术。所有的调查员都住在同一间 建设和使用最先进的研究核心实验室。这些核心提供了仪器 以及细胞生物学、分子生物学和成像方面的技术援助。这些设施由 高级研究科学家和一名设施协调员。试剂、临床标本和材料 为个别项目生成的数据将由研究核心处理，并将由所有调查人员共享。 来自个人研究人员的研究项目基于非常互动的方法，并提供了 该中心的多名研究人员和其他几名科学家之间的合作机会 机构。不同项目的项目主管和研究人员每周开会一次，进行监督和讨论 该中心的个别项目和科学计划的进展受到外部咨询的监督 在前列腺癌生物学和化学领域有多名成员的委员会。

Prostate cancer is the second leading of cancer deaths among american men after skin cancer. In African- American men, the incidence of prostate cancer is 65% higher and the mortality rate is more than double compared to Caucasian men. The reasons for this racial disparity in incidence and death rate due to this disease in African-American are poorly understood, but may involve both biological and environmental factors. The Center for Cancer Research and Therapeutic Development at Clark Atlanta University is building a comprehensive research program to investigate the cellular and genetic factors involved in transformation, angiogenesis and metastasis of prostate cancer and how these factors may differ in African- American men. Three research projects in this grant application will investigate 1. Role of TGFbeta signaling during different phases of prostate cancer, 2. Impact of androgen regulated immune/inflammatory pathways in prostate cancers, and 3. The role of SNAIL transcription factor and TGFbeta in bone metastasis of prostate cancer cells. In addition, we are proposing six pilot projects which will focus on different aspects of prostate cancer biology such as: the role of IL-10 in prostate cancer immunity, c-kit ligand and signaling in metastatic cancer cells, role of PI3-kinase isoforms in prostate cancer, chromatin remodeling and its impact in prostate cancer cells, role of sterols in prostate cancer cell proliferation and apoptosis, and development of highly sensitive techniques to detect prostate cancer biomarkers. All investigators are housed in the same building and have access to state-of- the Art research core laboratories. These cores provide instrumentation and technical assistance in cell biology, molecular biology, and imaging. These facilites are managed by a Senior Research Scientist and a Facilites Coordinator. The reagents, clinical samples and materials generated for individual projects will be handled by the research core and will be shared by all investigators. The research projects from individual investigators are based on very interactive approaches and provide opportunities for collaborations among multiple investigators at the Center and scientists at several other institutions. The Pis of different projects and the research staff meets once a week to monitor and discuss the progress of individual projects and the scientific program of the center is overseen by external advisory committees with several members in the area of prostate cancer biology and chemistry.