RESISTIVE TRAINING AND CHROMIUM PICOLINATE: EFFECTS ON INOSITOLS AND LIVER

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。阻力训练和吡啶甲酸铬：对老年人肌醇和肝肾功能的影响：本研究评估了阻力训练(RT)和补充或不补充吡啶甲酸铬(Cr-pic)对24小时尿肌肌醇、D-氯化肌醇和皮尼醇排泄的影响，以及肾和肝功能的临床指标。32名非糖尿病受试者，年龄62±4岁，每周进行两次RT，持续12wk，每天摄入924g铬(n=17)或安慰剂(n=15)。所有受试者的全身力量增加了20%，尿铬排泄量增加了47倍。尿肌醇、D-甲环肌醇和皮尼醇不随RT改变，也不受肌酸肌醇的影响。在基线和研究结束时，血清肾功能和肝功能指数均在临床正常范围内。这些结果表明，RT不影响尿肌醇的排泄。大剂量肌醇匹克与RT联合应用对尿肌醇排泄量及肝肾功能指标无明显影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Resistive Training and Chromium Picolinate: Effects on Inositols and Liver and Kidney Functions in Older Adults: This study assessed the effects of resistive training (RT) with or without chromium picolinate (Cr-pic) supplementation on the 24-h urinary excretions of myo-inositol, D-chiro-inositol, and pinitol, as well as clinical indices of kidney and liver functions. Thirty-two nondiabetic subjects, age 62 ¿ 4 y, performed RT twice weekly for 12 wk and consumed either 924 ¿g Cr/d as Cr-pic (n = 17) or a placebo (n = 15). Whole-body strength increased in all subjects by 20% and urinary chromium excretion increased 47-fold in the Cr-pic group. Urinary myo-inositol, D-chiro-inositol, and pinitol were not changed with RT or influenced by Cr-pic. Serum indices of kidney and liver functions were within clinically normal ranges at baseline and the end of the study. These results suggest that RT did not influence the urinary excretions of inositols. High dose Cr-pic did not influence the urinary excretion of inositols and the selected indices of kidney and liver functions in conjunction with RT.