PINITOL SUPPLEMENTATION NOT AFFECT INSULIN-MEDIATED GLUCOSE METABOLISM AND

补充松醇不会影响胰岛素介导的葡萄糖代谢

• 批准号: 7355262
• 负责人: W W CAMPBELL
• 金额: $ 0.29万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355262
• 关键词: PINITOL; SUPPLEMENTATION; AFFECT; INSULIN; MEDIATED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pinitol Supplementation Does Not Affect Insulin-Mediated Glucose Metabolism and Muscle Insulin Receptor Content and Phosphorylation in Older Humans: This study assessed the effect of oral pinitol supplementation on oral and intravenous glucose tolerances and on skeletal muscle insulin receptor content and phosphorylation in older people. Fifteen people (6 men, 9 women; age 66 ¿ 8 y; BMI 27.9 ¿ 3.3 kg/m2; hemoglobin A1c 5.39 ¿ 0.46%, mean ¿ SD) completed a 7-wk protocol. Subjects were randomly assigned to groups that during wk 2-7 consumed twice daily either a non-nutritive beverage (Placebo group, n = 8) or the same beverage with 1000 mg pinitol dissolved into it (Pinitol group, n = 7, total dose = 2000 mg pinitol/d). Testing was done at wk 1 and wk 7. In the Pinitol group with supplementation, 24-h urinary pinitol excretion increased 17-fold. The fasting concentrations of glucose, insulin, and C-peptide, and the 180-min area under the curve for these compounds, in response to oral (75 g) and intravenous (300 mg/kg) glucose tolerance challenges, were unchanged from wk 1 to wk 7 and were not influenced by pinitol. Also, pinitol did not affect indices of hepatic and whole-body insulin sensitivity from the oral glucose tolerance test and indices of insulin sensitivity, acute insulin response to glucose, and glucose effectiveness from the intravenous glucose tolerance test, estimated using minimal modeling. Pinitol did not differentially affect total insulin receptor content and insulin receptor phosphotyrosine 1158 and insulin receptor phosphotyrosine 1162/1163 activation in vastus lateralis samples taken during an oral-glucose-induced hyperglycemic and hyperinsulinemic state. These data suggest that pinitol supplementation does not influence whole-body insulin-mediated glucose metabolism and muscle insulin receptor content and phosphorylation in nondiabetic, older people.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。补充皮尼醇不影响老年人胰岛素介导的葡萄糖代谢和肌肉胰岛素受体含量和磷酸化：这项研究评估了口服皮尼醇对老年人口服和静脉血糖耐量以及骨骼肌胰岛素受体含量和磷酸化的影响。15人(男性6人，女性9人；年龄66±8岁；体重指数27.9±3.3 kg/m2；血红蛋白A1c 5.39±0.46%，平均SD)完成了7wk方案。受试者被随机分成两组，在wk 2-7期间每天饮用两次非营养饮料(安慰剂组，n=8)或相同饮料中加入1000 mg匹尼醇(Pinitol组，n=7，总剂量=2000 mg Pinitol/d)。在第1周和第7周进行测试。在补充匹尼醇的组中，24小时尿匹尼醇排泄量增加了17倍。口服(75g)和静脉注射(300 mg/kg)葡萄糖耐量挑战后，这些化合物的空腹葡萄糖、胰岛素和C-肽浓度以及曲线下180min的面积从第1周到第7周没有变化，也不受平尼醇的影响。此外，平尼醇不影响口服葡萄糖耐量试验的肝脏和全身胰岛素敏感性指数，以及使用最小模型估计的胰岛素敏感性指数、对葡萄糖的急性胰岛素反应和静脉葡萄糖耐量试验的葡萄糖有效性。在口服葡萄糖诱导的高血糖和高胰岛素状态下，皮尼醇对股外侧肌总胰岛素受体含量和胰岛素受体磷酸化酪氨酸1158和胰岛素受体磷酸化酪氨酸1162/1163的激活没有影响。这些数据表明，在非糖尿病的老年人中，补充匹尼醇不会影响全身胰岛素介导的葡萄糖代谢以及肌肉胰岛素受体含量和磷酸化。