CORE--IMAGING FACILITY

显微成像技术将广泛应用于所有拟议的MDCRC科学项目。肌萎缩症成像核心的目的是确保拟议的科学项目能够方便地获得实现其既定目标所需的各种成像技术。这将通过显著提高神经肌肉疾病中心神经肌肉病理实验室的成像能力来实现。此外，该实验室在处理肌肉组织方面的现有专业知识将与该机构内已建立的成像核心的现有专业知识相结合。核心将提供：1)专门的肌肉组织化学和免疫组织化学技术，2)荧光原位杂交（FISH）， 3)共聚焦显微镜和4)电子显微镜。核心内部也将提供专业知识，以帮助中心调查人员应用可能出现需求的其他技术

Microscopic imaging techniques will be used extensively in all of the proposed MDCRC scientific projects. The purpose of the Muscular Dystrophy Imaging Core is to insure that the proposed scientific projects have facilitated access to the various imaging techniques needed to fulfill their stated aims. This will be accomplished by significantly increasing the imaging capabilities of the Neuromuscular Disease Center's Neuromuscular Pathology Laboratory. In addition, the existing expertise of the Laboratory in handling muscle tissue will be combined to those available in established imaging cores within the institution. The Core will provide access to: 1) specialized muscle histochemical and immunohistochemical techniques, 2) fluorescent in situ hybridization (FISH), 3) confocal microscopy and 4) electron microscopy. Expertise will also be available within the cores to help Center investigators apply other techniques, whose need may arise during the conduct of the proposed studies.