UNIVERSITY OF HAWAII SNRP

本提案是为响应RFA NS-99-001而准备的，并描述了该少数民族机构的一个专门的神经科学研究计划。贝克西神经生物学实验室为这一SNRP提供了一个合适的地点，并将因申请获奖而大大加强。已经选出了三名初级教员，他们制定了合作提案，涉及一家研究密集型机构的一名研究人员。项目1--涉及从蛇毒中提取的新型神经活性化合物的特征。这项工作将与约翰·霍普金斯大学的研究人员合作进行，他们以这一领域的工作而闻名。项目2--询问位于中枢神经系统内的细胞毒性T淋巴细胞是否导致对神经毒力的HIV-1毒株的选择，从而作为这种选择过程的延迟结果而引发艾滋病痴呆综合征。这项工作将与西雅图华盛顿大学的一名经验丰富的调查员合作进行。项目3--寻求确定在西伯利亚特定人群中发现的一种脑脊髓炎的致病微生物的特征。然而，移民中的流行率与当地人口中的流行率相同。这项工作将与NINDS在传染病研究方面经验丰富的内部调查员合作进行。已经建立了内部和外部咨询委员会，以进一步帮助选定的教师发展他们独立的神经科学研究事业。这一奖项将大大增加未得到充分服务的少数族裔在该机构获得高质量神经科学研究培训的机会。

This proposal has been prepared in response to RFA NS-99-001, and describes a Specialized Neuroscience Research Program for this Minority Institution. The Bekesy Laboratory of Neurobiology provides an appropriate site for this SNRP and would be greatly strengthened by the requested award. Three junior faculty have been selected, who have developed collaborative proposals involving an investigator at a research- intensive institution. Project 1- involves characterization of novel neuroactive compounds from Cnidaria venoms. This work will be carried out in collaboration with investigators from Johns Hopkins University who are well-known for their work in this area. Project 2- asks whether cytotoxic T lymphocytes located within the central nervous system lead to selection on neurovirulent strains of HIV-1 thus initiating AIDS dementia complex as a delayed result of this selection process. This work will be carried out in collaboration with an experienced investigator at the University of Washington, Seattle. Project 3- seeks to characterize the microbial agent responsible for a form of encephalomyelitis found in a specific Siberian population. However, prevalence is the same in-migrants as in the native population. This work will be carried out in collaboration with an NINDS Intramural investigator experienced in study of infectious diseases. Internal and External Advisory committees have been established to further assist the selected faculty in developing their independent neuroscience research careers. This award will substantially improve opportunities for underserved minorities to obtain high-quality research training in neurosciences at this institution.