WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTER

全国妇女健康研究（SWAN I）于1994年9月由国家老龄问题研究所资助，以响应题为“老年妇女的更年期和健康”的RFA AG-94-002。RFA确定了四个主要目标，并要求建立一个协调中心、临床研究中心和一个中央内分泌实验室。该协调中心申请是一组申请的组成部分，包括七个诊所和中央内分泌实验室，以继续SWAN额外五年。 SWAN II建议继续在现有奖项下开始的科学，以所获得的经验为基础，进一步提高研究的科学贡献，以了解更年期和衰老对中老年妇女健康的作用。为了促进实现本次更新的科学目标，协调中心（CC）将实现以下四个目标。1. CC将维护并继续加强当前的分布式数据管理系统（DMS），以收集、整合、质量控制和记录直接从临床研究中心和中心实验室收集的分析数据。 2.协调委员会将继续支持制定和实施所有核心和次核心SWAN协议，包括科学投入、表格设计、操作手册、现场工作人员的培训和认证，以及通过现场访问、定期电话会议和数据审查进行持续的质量控制和标准化测量。 3. CC将继续与研究中心统计学家合作，提供研究设计和分析方法方面的统计经验，协调所有分析数据集的开发和维护，并完成对手稿和演示文稿的分析。 在行政方面，CC将继续通过电话会议和会议支持，以及通过维护指导委员会（SC）和执行委员会（EC）会议记录，协助咨询小组（AP）会议记录，维护研究目录，委员会名单和SWAN网站，协调和支持SWAN行政结构。 CC还将保存所有研究方案文件。

The study of Women's Health Across the Nation (SWAN I) was funded on September 1994 by the National Institutes on Aging in response to RFA AG-94-002 entitled "Menopause and Health in Aging Women." The RFA identified four primary objectives and called for a Coordinating Center, Clinical Sites and a central endocrinology laboratory. This Coordinating Center application is a component of a set of applications, including seven clinic sites and central endocrinology laboratory, to continue SWAN for an additional five years. SWAN II proposes to continue the science begun under the current awards, building on the experience gained to further enhance the scientific contribution of the study to our knowledge of the role of menopause and aging on health in mid-aged and older women. To facilitate addressing the scientific goals of this renewal, the Coordinating Center (CC) will meet the following four goals. 1. The CC will maintain and continue to enhance the current distributed data management system (DMS) to collect, integrate, quality control and document for analysis data collected directly from the clinic sites and from the central laboratories. 2. The CC will continue to support the development and implementation of all core and sub-core SWAN protocols, including scientific input, forms design, manuals of operation, training and certification of site staff and on-going quality control and standardization of measurement through site visits, regular conference calls and review of data. 3. The CC will continue to provide, in collaboration with site statisticians, statistical experience in study design and analytic approach, coordinate the development of and maintain all analytic data sets and complete analyses for manuscripts and presentations. Administratively, the CC will continue to coordinate and support the SWAN administrative structure through conference call and meeting support, and by maintaining Steering Committee (SC) and Executive Committee (EC) minutes, assisting with Advisory Panel (AP) minutes, maintaining the study directory, committee lists and the SWAN Web Site. The CC will also maintain all study protocol documentation.