WOMEN AND INFANTS TRANSMISSION STUDY--CHICAGO

描述（改编自申请人摘要）：申请人声明， WITS是一项关于围产期HIV感染的开创性研究。总体目标 WITS III将研究围产期的机制和辅助因素， 传播，检查预测疾病进展的因素， 急性感染的过程，并检查怀孕对艾滋病毒的影响 感染 芝加哥联合会自2000年以来一直是研究小组的成员。 WITS I的开始它由伊利诺伊大学的研究中心组成， 芝加哥、库克县医院、西北大学和儿童医院 纪念医院。该项目共招募了309名感染艾滋病毒的孕妇和237名 他们的婴儿。它将继续招募50名艾滋病毒感染孕妇 每年。 根据申请人的说法，芝加哥财团提供了科学的 通过参与国家WITS议程， 在委员会和工作组担任领导职务的成员， 通过提出和执行具体议定书， 介绍和公布结果。质量的措施， 入学率、保留率和数据收集表明， 工作的质量。 该申请还提出了一个科学合作， 独立资助的调查员艾伦·兰迪博士该研究将审查 HIV感染孕妇的免疫功能。它将审查在 更深的功能变化，通常发生在怀孕期间， 艾滋病病毒感染对这些变化的影响，对免疫系统的影响 对围产期传播的影响，以及对艾滋病毒疾病进展的影响。的 申请人表示，拟议的研究密切遵循WITS的目标 III并将为研究增添深度和质感。 拟议的计划将继续芝加哥小组在WITS III中的工作。 该小组的创新特点、工作质量和效率， 据申请人说，这将加强整个科学议程， WITS III.

DESCRIPTION (adapted from applicant's abstract): The applicants state that WITS is a seminal study of perinatal HIV infection. The overall objectives of WITS III will be to examine the mechanisms and co-factors of perinatal transmission, to examine the factors predicting disease progression and course of acute infection, and to examine the impact of pregnancy on HIV infection. The Chicago Consortium has been a member of the study group since the beginning of WITS I. It consists of study sites at University of Illinois at Chicago, Cook County Hospital, Northwestern University, and Children's Memorial Hospital. It has enrolled 309 HIV infected pregnant women and 237 of their infants. It will continue to enroll 50 HIV infected pregnant women annually. The Chicago consortium, according to the applicants, has provided scientific and managerial leadership to the national WITS agenda through participation of its members in leadership positions on committees and working groups, through the proposal and implementation of specific protocols, and the presentation and publication of results. The measures of quality of enrollment, retention, and data collection have demonstrated the high quality of the work. The application also proposes a scientific collaboration with an independently funded investigator, Dr. Alan Landay. The study will examine the immune function in pregnant HIV infected women. It will examine in greater depth the function changes that normally occur in pregnancy, the effect of HIV infection on these changes, the effect of the immune changes on perinatal transmission, and the effect on HIV disease progression. The applicants state that the proposed study closely follows the goals of WITS III and will add depth and texture to the study. The proposed plan will continue the work of the Chicago team in WITS III. The innovative characteristics, quality of work and efficiency of the group, according to the applicants, will enhance the overall scientific agenda of WITS III.