SCHISTOSOMIASIS AND CHAGAS DISEASE IN BRAZIL

我们建议扩展和扩大跨学科的研究计划， 曼氏和恰加斯血吸虫病免疫学基础的研究 巴西米纳斯吉拉斯的一种疾病。 该计划将整合 四所美国大学的五个实验室的专业知识， 巴西贝洛奥里藏特FIOCRUZ研究所的科学家们在一个 共同努力定义基本免疫学，免疫调节， 这些疾病的免疫病理学。 与血吸虫病有关的项目 将包括检查细胞调节的独特型基础， 增殖和肉芽肿形成，以及质量评估 免疫系统对特定抗原的反应。 项目 查加斯病包括疾病的基本免疫病理学。 所有项目都将联网，以便定义抗原和抗血清 将酌情分享，并定期举行全体会议， 参与的实验室将分享数据，评估进展， 在每个项目中，并促进技术转让， laboratories.

We propose to extend and expand a research program of interdisciplinary studies on the immunological basis of schistosomiasis mansoni and Chagas' disease in Minas Gerais, Brazil. The program would integrate the expertise of five laboratories at four American universities with those of scientists at the FIOCRUZ Institute in Belo Horizonte, Brazil in a concerted effort to define the basic immunology, immunoregulation, and immunopathology of these diseases. Projects related to schistosomiasis would include examining the idiotypic basis of the regulation of cell proliferation and granuloma formation, and the assessment of the quality of the immune response to defined antigens in humans. Projects in Chagas' disease would include the basic immunopathology of the disease. All projects would be networked so that defined antigens and antisera would be shared, when appropriate, and regular meetings of all participating laboratories would be held to share data, assess progress in each project, and to facilitate technology transfer between the laboratories.