CLINICAL IMMUNE SURVEY OF THE LONGITUDINAL PROJECT PARTICIPANTS

工作总结：本项目利用外周血， 参与巴尔的摩老龄化纵向研究（BLSA）的参与者， 深入了解生物、生化和分子机制 与年龄相关的人体免疫功能变化。 一些 研究表明，从老年人中获得的人T淋巴细胞 个体表现出对各种免疫应答的改变， 疫苗和多克隆刺激物。 相比 对于从年轻个体获得的免疫细胞，老年白细胞也 显示出蛋白质磷酸化、细胞因子 合成和基因表达以及细胞周期进程。

Summary of Work: This projects utilizes peripheral blood obtained from participants in the Baltimore Longitudinal Study of Aging (BLSA) to gain insight into the biological, biochemical, and molecular mechanisms underlying age-associated changes in human immune function. A number of studies have suggested that human T lymphocytes obtained from aged individuals exhibit an altered immune response to various immunological vaccines and polyclonal stimuli both in vivo and in vitro. In comparison with immune cells obtained from younger individuals, aged leukocytes also display distinctive patterns of protein phosphorylation, cytokine synthesis and gene expression, and cell-cycle progression.