From planar chirality to matched and mismatched dendrimers

对日益高效和有效的药物的需求需要通过越来越高效和有效的制造这些分子的方法来满足。许多药物都是手性的，这意味着它们以两个镜像的形式存在。这些镜像在与人体复杂的化学物质的相互作用中表现出很大的不同，因此出于安全和经济的原因，只以两种形式中的一种来制造药物是很重要的，即具有最佳临床效果的一种。最有效的方法之一是使用少量的手性催化剂，最终源于自然产生的手性，在通往目标药物的途中产生大量关键分子。在这个项目中，我们计划使用在我们的实验室中发现的一系列反应，使我们能够快速创建包含以前难以获得的对称性的分子，以创建新的手性催化剂。这些催化剂将在几个关键反应中进行测试，最有希望的将进一步开发，以便它们最终可能用于制药生产。

The demand for increasingly more efficient and effective pharmaceuticals needs to be met by increasingly more efficient and effective methods of making these molecules. Many pharmaceuticals are chiral, which means that they exist as two mirror images. These mirror images often behave quite differently in their interactions with the body's complex chemistry, and so it is important for safety and economic reasons to make pharmaceuticals in just one of its two forms i.e. the one which has the best clinical effect. One of the most efficient ways of doing this is by using a small amount of a chiral catalyst, ultimately derived from chirality created by nature, to generate large amounts of a key molecule en route to the target pharmaceutical. In this project we plan to use a series of reactions discovered in our laboratories, which enables us to rapidly create molecules containing previously difficult-to-access symmetries, to create new chiral catalysts. The catalysts will be tested in several key reactions and the most promising will be developed further so that they may ultimately be used in pharmaceutical manufacture.