MSKCC Research Center for Botanical Immunomodulators

纪念斯隆-凯特琳癌症中心的植物研究中心将由一个 由资深科学家组成的多学科合作团队，在每个领域都拥有实验室和临床专业知识，以实现我们的目标。该中心将对具有先前描述的免疫调节活性的五种植物补充剂（紫锥菊，黄芪，姜黄，灰树花和TJ-48草药配方）进行系统研究，解决植物成分，作用机制，临床前模型的开发以及临床应用。该中心汇集了基础科学和临床免疫学，肿瘤学，传染病，植物学，有机化学和补充医学的领导者，分为四个项目和两个核心。利文斯顿的项目将研究植物对免疫系统传入臂的影响，以确定植物如何调节抗原识别和启动免疫反应。Cheung的项目将解决对传出臂的影响 以确定植物如何增强效应细胞活性和分子靶点。Pamer的项目将研究这两种效应的整合，通过宿主抗感染反应的动物模型确定它们在多室免疫系统中的最终结果。Cassileth的项目将解决人类用途：生物标志物和安全性的基本问题。行政核心将协调中心内的研究活动，整合研究成果，并促进研究和咨询小组之间的信息交流。植物学核心将使用基因组和化学技术对研究植物进行认证和标准化，对植物提取物进行分类以表征成分，并分离活性成分以供进一步研究。它将有助于研究植物药的制备，以满足FDA级质量标准。总之，这些项目涵盖了植物免疫调节剂研究的多个方面，涉及组成，机制，标准化和人类生物标志物，以及宿主免疫反应的全方位，从分子和细胞研究到动物和人类研究。我们的目标是推进代表性植物免疫调节剂的科学和知识基础，开发植物研究的模型实验系统，并生成基于证据的信息来指导人类使用。

The Botanical Research Center at Memorial Sloan-Kettering Cancer Center will consist of a multidisciplinary collaborative team of senior scientists with laboratory and clinical expertise in each area required to reach our goal. The Center will pursue systematic investigation of five botanical supplements with previously described immunomodulatory activities (Echinacea, Astragalus, Turmeric, Maitake, and TJ-48 herbal formulation), addressing composition of the botanicals, mechanism of action, development of preclinical models, and translation to clinical application. The Center brings together leaders in basic science and clinical immunology, oncology, infectious diseases, botanicals, organic chemistry, and complementary medicine in four projects and two cores. Project by Livingston will study the effect of botanicals on the afferent arm of the immune system to determine how botanicals modulate antigen recognition and initiate immune response. Project by Cheung will address impact on the efferent arm to determine how botanicals enhance effector cell activity and molecular targets. Project by Pamer will investigate the integration of these two effects, determining their end result in the multi-compartment immune system via animal models of host response against infection. Project by Cassileth will address issues essential to human use: biomarkers and safety. The Administrative Core will coordinate research activities within the center, integrate research findings, and facilitate information exchange among research and advisory groups. The Botanical Core will authenticate and standardize study botanicals using genomic and chemical technology, fractionate botanical extracts to characterize constituents, and isolate active constituents for further study. It will aid preparation of study botanicals to meet FDA-level quality standards. Together, these projects encompass multiple dimensions of botanical immunomodulator research, addressing composition, mechanism, standardization and human biomarkers, and the full spectrum of host immune response, from molecular and cellular studies to animal and human research. We aim to advance the science and knowledge base of representative botanical immunomodulators, develop model experimental systems for botanical research, and generate evidence-based information to guide their human use.