PROGRAM FOR GENETIC INTERACTIONS (PROGENI) NETWORK DATA COORDINATING CENTER

描述（由申请人提供）： PROGENI网络是四个家族药物遗传学研究的集合，这些研究希望利用在几种受控环境中测量基因表型表达所产生的基因发现能力。我们的目标是在家族设计的背景下，使用候选基因和基因组方法来发现响应基因。收集了大量的多种族和广泛的地理分布的家庭，在干预前后进行表型分析。选定的候选基因进行了检查，全基因组连锁小组正在完成。该更新期专门用于分析和随访基因分型。虽然干预措施和主要结局因研究而异，但PROGENI网络组件研究具有重要的共同关键方面，最重要的是，需要有效的统计分析方法来发现干预反应表型的基因。PROGENI数据协调中心为整个网络提供行政和科学支持，包括研究网站、数据汇集、质量控制、分析研讨会以及开发和评估所有研究的新统计分析方法。

DESCRIPTION (provided by applicant): The PROGENI network is a collection of four family pharmacogenetic studies which hope to exploit the gene-finding power that arises from measuring the phenotypic expression of genes in several controlled environments. The goal is to discover genes for response using both candidate gene and genomic approaches in the context of family designs. Large numbers of families of multiple ethnicities and wide geographical dispersion were collected, phenotyped before and after intervention. Selected candidate genes were examined and genome-wide linkage panels are being completed. This renewal period is devoted to analysis and follow-up genotyping. Although the interventions and primary outcomes differ from study to study, the PROGENI network component studies have important key aspects in common, most importantly, the need for efficient statistical analysis methods for gene finding for intervention response phenotypes. The PROGENI Data Coordinating Center provides both administrative and scientific support to the entire network, including study website, data pooling, quality control, Analysis Workshops, and development and evaluation of novel statistical methods of analysis for all studies.