Training in Pharmacoinformatics(RMI)

要求支持9个博士前和6个博士后职位，以建立药物信息学跨学科领域的培训计划。该计划的提出是因为目前发现新药的方法没有充分利用生物信息学，基因组学，计算和其他领域的进步，因此，药物发现的速度落后于这些领域的突破。近年来，正在开发的新药的管道没有增加，因此，极少数新药承担了越来越昂贵的过程的巨大成本，该过程是在开发大量新信息和将其整合到可用和可访问系统中的能力之前发展起来的。我们提出了一个全面的综合方案， 下一代科学家：（1）使用信息学方法来鉴定作为药物靶向候选物的生物分子，（2）使用结构基因组学、化学信息学和基于结构的设计来开发化学品家族以靶向选定的生物分子和结构，以及（3）使用ADMET在生物学测试之前，本发明提供了用于选择活性药物候选物的功效（吸收、分布、代谢、消除和毒性）分析和计算预测的方法。培训将强调计算机模拟方法来实现这些目标。机构间培训将由来自墨西哥湾沿岸联盟（Baylor医学院，M。D. 安德森癌症中心，赖斯大学，休斯顿大学，得克萨斯大学休斯顿健康科学中心和得克萨斯大学加尔维斯顿医学分支）在休斯顿-加尔维斯顿地区，并将利用研究培训与共同导师，教学课程，研讨会，务虚会和职业发展活动。博士前学员将在他们的家乡机构录取并获得第一年的支持，并将在研究生培训的第2-4年的竞争基础上获得奖学金。 国内机构将授予博士学位。博士后培训生将获得最多两年的支持。拟议的计划旨在培养未来的领导者在药物发现研究。

Support is requested for 9 predoctoral and 6 postdoctoral positions to establish a training program in the interdisciplinary area of Pharmacoinformatics. This program is proposed because current approaches to the discovery of new drugs have not fully capitalized on advances in bioinformatics, genomics, computing and other fields, and consequently, the rate of drug discovery has lagged behind breakthroughs in these areas. The pipeline of new drugs under development has not increased in recent years, and a very small number of new drags are thus responsible for bearing the enormous costs of an increasingly expensive process that evolved prior to development of massive amounts of new information and the ability to integrate it into usable and accessible systems. We propose a comprehensive, integrated program to train the next generation of scientists to: (1) use informatics approaches to identify biomolecules that are candidates for drug targeting, (2) use structural genomics, chemoinformatics, and structure-based design to develop families of chemicals to target selected biomolecules and structures, and (3) use ADMET (absorption, distribution, metabolism, elimination, and toxicity) profiling and computational predictions of efficacy to select viable drag candidates prior to biological testing. Training will emphasize in silico approaches to achieve these goals. Inter-institutional training will be conducted by sixty-three training faculty from the six institutions of the Gulf Coast Consortia (Baylor College of Medicine, M. D. Anderson Cancer Center, Rice University, the University of Houston, The University of Texas Health Science Center at Houston, and The University of Texas Medical Branch at Galveston) in the Houston -Galveston area and will utilize research training with co-mentors, didactic courses, seminars, retreats, and career development activities. Predoctoral trainees will matriculate and receive first year support at their home institutions, and stipends will be awarded on a competitive basis for years 2-4 of graduate training. The home institution will award the Ph.D. Postdoctoral trainees will receive support for two years maximum. The proposed program is designed to train future leaders in drag discovery research.