FUNCTIONAL-BEHAVIOR CORRELATES BETWEEN ALZHEIMER'S DISEASE AND FRONTOTEMPORAL

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。冷漠是阿尔茨海默病(AD)和额颞性痴呆(FTD)最常见的神经心理症状。将利用局部脑血流(RCBF)和磁共振成像(MRI)的差异来比较两种疾病患者与冷漠相关的局部脑功能和结构的差异。AD和FTD患者将从加州大学洛杉矶分校行为神经学专科诊所的随访中识别出来。冷漠的存在将根据两组患者的神经精神病学问卷(NPI)来确定。此外，正面行为问卷(FBI)将被用来确认FTD受试者是否存在这种症状，以解决NPI可能比FTD对AD的冷漠更敏感的担忧。功能差异将用~(99m)Tc99m标记的己基甲基丙二醇胺肟单光子发射计算机断层扫描(Tc99mHMPAO SPECT)检查。有冷漠的AD和FTD受试者将与匹配的无冷漠的AD和FTD患者进行比较。我们假设，在这两个患者群体中，大脑区域不同和相似的结构和功能差异将与冷漠的发展有关，特别是双侧前扣带回皮质、背外侧前额叶皮质以及包括丘脑和基底节在内的皮质下结构的功能低下。形态计量学和功能研究将分别使用方差分析(ANOVA)进行比较。分体积阈值(SVT)将被用来确定60个感兴趣区域(ROI)中每一个区域的局部脑血流量的平均值和方差。然后，将使用三因素方差分析(根据ROI进行疾病冷漠)来检查试验组之间局部脑血流的差异。通过区域交互作用的冷漠效应引起的重大疾病将支持实验假说。随后将使用Fishers最小显着差异检验来检验个体组差异的显着性。类似地，将使用三因素方差分析来检查患者MRI扫描中60个感兴趣区的体积差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Apathy is the most common neuropsychitric symptom of both Alzheimer¿s disease (AD) and frontotemporal dementia (FTD). Differences in regional cerebral blood flow (rCBF) and Magnetic Resonance Imaging (MRI) will be used to compare differences in regional brain function and structure associated with apathy in patients with both diseases. AD and FTD patients will be identified from those followed in subspecialty behavioral neurology clinics at UCLA. The presence of apathy will be determined on the basis of the Neuropsychiatric Inventory (NPI) in both patient groups. Additionally, the Frontal Behavioral Inventory (FBI) will be used to confirm the presence of the symptom in FTD subjects, to address the concern the NPI may be more sensitive to apathy in AD compared to FTD. Functional differences will be examined with Technetium Tc 99m-labeled hexylmethylpropylene amineoxime single photon emission computerized tomography (Tc 99m HMPAO SPECT) scans. AD and FTD subjects with apathy will be compared to matched AD and FTD patients without apathy. We hypothesize that distinct and similar structural and functional differences in brain regions will be associated with development of apathy in these two patients populations, specifically, bilateral hypofunctioning of the anterior cingulate cortex, dorsolateral prefrontal cortex, and subcortical structures including the thalamus and basal ganglia. Morphometric and functional studies will be compared separately using Analysis of Variance ( ANOVA). Subvolumetric threshold (SVT) will be employed to determine a mean and variance for regional cerebral blood flow in each of sixty regions of interest (ROI). A three way analysis of variance (disease by apathy by ROI) will then be used to examine differences in regional cerebral blood flow between experimental groups. A significant disease by apathy by region interaction effect would support the experimental hypothesis. Significance of individual group differences will then be examined post hoc using Fishers Least Significant Difference test. Similarly, a three way ANOVA will be used to examine volumetric difference in 60 ROIs in the patients MRI scans.