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Brain and behavior correlates of prenatal cannabis exposure

产前大麻暴露的大脑和行为相关性

基本信息

批准号：
10734717
负责人：
STEPHEN R DAGER
金额：
$ 69.61万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-15 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734717
关键词：
ATOD Affect Age Age Months Alcohols Amygdaloid structure Animal Experimentation Animals Antiemetics Anxiety Attention Behavior Behavioral Binding Biological Assay Birth Birth Weight Brain Brain imaging Brain region COVID-19 pandemic Cannabidiol Cannabinoids Cannabis Cell Adhesion Molecules Cerebellum Complementary and alternative medicine Conceptions Conscious Consumption Data Development Diffusion Magnetic Resonance Imaging Disease Dopamine D2 Receptor Dose Early Diagnosis Educational Status Endocannabinoids Enrollment Evaluation Exclusion Criteria Exhibits Female First Pregnancy Trimester Frequencies Functional Magnetic Resonance Imaging Goals Growth Head circumference Health Health Benefit Human Illicit Drugs Infant Influentials Label Legal Legal Status Length Magnetic Resonance Imaging Measures Medicine Memory Modernization Monitor Mothers Multimodal Imaging Nausea and Vomiting Neonatal Neurodevelopmental Disorder Neuropsychology Newborn Infant Odors Outcome Outcomes Research Pacific Northwest Participant Pathway interactions Patient Self-Report Perception Persons Pharmacologic Substance Placenta Population Pregnancy Pregnant Women Product Labeling Property Prospective Studies Protocols documentation Psychotropic Drugs Recreation Regulation Reporting Research Risk Second Pregnancy Trimester Sex Differences Signal Transduction Sleep Stimulus Structure System Testing Tetrahydrocannabinol Third Pregnancy Trimester Time Tobacco Update Urine Visit Washington Woman Work adverse outcome autism spectrum disorder behavior measurement behavioral outcome brain dysfunction cannabinoid receptor density design drug of abuse experience fetal marijuana exposure follow up assessment frontal lobe imaging study in utero indexing infancy infant outcome innovation male marijuana legalization marijuana use marijuana use in pregnancy marijuana user maternal marijuana use motor behavior myelination neural neurobehavior neurobehavioral neurodevelopment pain reduction polysubstance use pregnant prenatal prenatal exposure programs prospective receptor density recruit response reward processing symptom management white matter

项目摘要

Cannabis use during pregnancy has increased substantially, in conjunction with widespread decriminalization/legalization, changing public perceptions about harm, and evidence of cannabis's antiemetic properties. Prior outcomes research on prenatal cannabis exposure is narrow in scope, as these older studies included research participants with polysubstance use (e.g., tobacco, alcohol, illicit drugs). In addition, prior research also likely underestimated potential risks specific to cannabis use during pregnancy because modern strains are 10x more potent than they were 40 years ago. We propose to study neurodevelopment in infants exposed in utero to cannabis using state-of-the-art MRI and behavioral measures. Maternal cannabis use will be measured prospectively using weekly reports validated with labels and urine-based assays. By focusing on infancy, we aim to characterize cannabis-induced brain changes at a time when environmental effects are minimized and are less influential than at older. In addition, we will test the hypothesis that prenatal cannabis exposure is more detrimental to male than females. To test our hypotheses, we will recruit 200 pregnant people (where the mother uses cannabis, but not other drugs, tobacco, or alcohol) and 170 pregnant control participants matched on education level. Infants will receive a neonatal neurobehavioral exam and multi-modal imaging (functional magnetic resonance imaging, diffusion tensor imaging, and structural MRI) under natural sleep at 2-4 weeks-of-age and extensive neuropsychological follow-up assessments at 6 and 18 months. This program of research aims to clarify potential health risks, enabling pregnant people to make better-informed choices surrounding cannabis use during pregnancy.

怀孕期间大麻的使用已大幅增加，同时普遍存在