AMINO TERMINAL DOMAIN OF IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT TYPE 2 (G2-ATD)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。离子型谷氨酸受体是一种寡聚配体门控离子通道，负责介导大脑中的快速兴奋性神经传递。大胞外域由氨基末端结构域(ATD)和配体结合域(S1S2)组成。尽管S1S2的作用未能得到很好的描述，但ATD的目的不太清楚。然而，它被认为介导受体组装，促进树突棘的形成，并参与受体运输。ATD的三维结构将有助于阐明一些关于组装的问题，甚至可能是与突触靶向蛋白的假定相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ionotropic glutamate receptors are oligomeric ligand-gated ion channels responsible for mediating fast excitatory neurotransmission in the brain. The large extracellular domain is composed of an amino terminal domain (ATD) and a ligand-binding domain (S1S2). Although the role of S1S2 has been failry well delineated, the purpose of the ATD is less clear. However, it is thought to mediate receptor assembly, contribute to dendritic spine formation, and participate in receptor trafficking. The three-dimensional structure of ATD would help clarify some issues regarding assembly and perhaps even putative interactions with synaptic targeting proteins.