AIR POLLUTION AND CARDIAC VULNERABILITY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。该合作项目正在与NIH/NIEHS P01 ES 09825项目的研究人员进行，环境颗粒对人类心脏脆弱性的影响。这项补助金的目的是确定暴露于环境空气污染物的影响可能导致心血管事件的机制。其目标是：1）描述高危人群的生理状态; 2）足够详细地监测暴露情况，以描述和量化推定的环境因子; 3）对心脏功能进行详细和适当的持续测量，以评估心脏的自主反应; 4）将这些潜在的发现与暴露于浓缩空气颗粒的动物中发现的发现相关联。PhysioNet研究人员正在帮助使用资源开发的新方法分析心脏搏动间隔时间序列，以测试以下假设：空气污染水平的增加可能会降低心脏迷走神经张力并降低心率调节的复杂性，从而增加不良心血管事件的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This collaborative project is being conducted with investigators from the Program Project NIH/NIEHS P01 ES09825, Effects of ambient particles on human cardiac vulnerability. The goal of this grant is to identify mechanisms whereby effects of exposure to ambient air pollutants could result in cardiovascular events. The aims are: 1) characterize the physiologic state of at-risk groups; 2) monitor exposure in sufficient detail to characterize and quantify the putative environmental agents; 3) make detailed and appropriately sustained measures of cardiac function that are relevant to assessing the autonomic response of the heart; and 4) correlate these potential findings with those found in animals exposed to concentrated air particles. PhysioNet investigators are helping to analyze cardiac interbeat interval time series using new methods developed at the Resource to test the hypothesis that increasing levels of air pollution may reduce cardiac vagal tone and decrease the complexity of heart rate regulation, thereby increasing risk of adverse cardiovascular events.