ENDOTHELIAL CELL DYNAMICS & COMPLEXITY THEORY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项工作的目的是应用复杂性理论来理解健康和疾病中的内皮细胞功能。该资源正在协助Aird博士（NHLBI支持）发展我们对内皮功能非线性复杂性的理解。Aird博士提出了一个基于资源调查员工作的模型（Crit Care Med 2002; 20; Supplement.其中健康的内皮保持广泛的反应，因此是高度活跃的;而功能障碍的内皮被锁定在一个狭窄的反应范围内，接近单一的稳态和最终的静止。这些概念为理解多器官功能障碍综合征中内皮细胞功能障碍的病理生理学奠定了基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this work is to apply complexity theory to understanding endothelial cell function in health and disease. The Resource is assisting Dr. Aird (NHLBI support) in developing our understanding of the nonlinear complexity of endothelial function. Dr. Aird has proposed a model based on the work of Resource investigators (Crit Care Med 2002; 20; Supplement. In press) in which healthy endothelium retains a broad range of responses and is therefore highly active; whereas dysfunctional endothelium becomes locked into a narrow range of responses, approaching a single steady state and eventual quiescence. These concepts lay a foundation for understanding the pathophysiology of endothelial cell dysfunction in the multiple organ dysfunction syndrome.