Integrated Biostatistical Training for CVD Research

描述(由申请人提供)： 这项申请提出了一种新颖的、综合的生物统计学博士前培训计划，重点是为受训人员在心血管疾病研究领域的职业生涯做准备。在这个令人振奋的心血管疾病研究的新时代，严重缺乏有能力应对当前和新出现的挑战的熟练生物统计员，需要进行培训，正式整合多学科环境中合作的有针对性的经验，掌握有效应用复杂的生物统计技术和研究开发新方法所需的统计学理论基础，并高度重视沟通和领导技能。该项目将是北卡罗来纳州立大学(NCSU)统计系和杜克临床研究所(DCRI)的联合努力，利用世界上最大的统计学研究生项目之一和一个研究机构之间的现有合作伙伴关系，该研究机构是同类研究中最大的，是心血管疾病研究前沿的国际知名研究人员的发源地。这项为期五年的计划将支持最多5名学员，并将包括在NCSU严格学习统计理论，包括概率、推理、线性和其他统计模型、测量理论和高级概率，以及高级统计推理，以及统计方法，包括临床试验设计/分析、纵向数据分析、生存分析和前沿专题；心血管疾病科学基础方面的培训；研究责任和伦理学方面的课程工作；以及沟通和领导技能方面的广泛正式和经验培训。受训人员将被逐步介绍给DCRI心血管疾病研究，演变为完全合作的学徒制度，在这种情况下，他们将被整合为DCRI项目团队的职能成员。通过这种学徒期以及正式的课程和研讨会，学员将在心血管疾病科学方面获得广泛的工作知识和专业知识，这将使他们在完成项目后立即为心血管疾病研究做出贡献。受训者将被分配一个机构间导师小组，由每个地点的初级生物统计学家导师和DCRI的一名二级临床医生导师组成，后者将合作指导他们完成所有方面的工作。论文研究将包括开发和评估新的统计方法，灵感来自于受训人员在心血管疾病研究合作中遇到的挑战。

DESCRIPTION (provided by applicant): This application proposes a novel, integrated program for pre-doctoral training in biostatistics focused on preparing trainees for careers in cardiovascular disease research. The critical shortage of skilled biostatisticians equipped to address ongoing and emerging challenges in this exciting new era of cardiovascular disease research calls for training that formally integrates targeted experience in collaboration in a multidisciplinary environment, mastery of the theoretical underpinnings of statistics required for valid application of sophisticated biostatistical techniques and for research on development of new methodology, and strong emphasis on communication and leadership skills. The program will be a joint effort of the Department of Statistics at North Carolina State University (NCSU) and the Duke Clinical Research Institute (DCRI), capitalizing on an existing partnership between one of the largest graduate programs in statistics in the world and a research institution that is the largest of its kind and home to internationally-known researchers at the forefront of cardiovascular disease research. The five-year program will support up to 5 trainees and will involve rigorous study at NCSU of statistical theory, including probability, inference, linear and other statistical models, measure theory and advanced probability, and advanced statistical inference, and statistical methods, including clinical trials design/analysis, longitudinal data analysis, survival analysis, and cutting-edge special topics; training in fundamental aspects of cardiovascular disease science; course work in research responsibility and ethics; and extensive formal and experiential training in communication and leadership skills. Trainees will be introduced to DCRI cardiovascular disease research gradually, evolving to a full collaborative apprenticeship in which they are integrated as functioning members of DCRI project teams. Through both this apprenticeship and formal courses and seminars, trainees will develop extensive working knowledge and expertise in cardiovascular disease science that will position them to make immediate contributions to cardiovascular disease research upon completion of the program. Trainees will be assigned an inter-institutional mentorship team consisting of primary biostatistician mentors at each site and a secondary clinician mentor at DCRI, who will collaborate in guiding them through all aspects. Dissertation research will involve development and evaluation of novel statistical methodology inspired by challenges encountered in trainees cardiovascular disease research collaborations.