Instituitional Training Grant in Pediatric Cardiology

描述(由申请人提供)： 拟议的儿科心脏病(SP)培训资助计划的总体目标是将儿科研究员培养成训练有素的研究人员，有可能在国家先天性心脏病研究议程中担任领导角色。通过这个为期两年的培训计划，他们将获得对先天性心脏病的原因、病理机制和结果进行特殊的临床和基础科学研究的能力。 接受过研究培训的儿科心脏病专家很少，而接受过研究培训的儿科心脏病专家相对较少。 奖学金毕业生有成功开展这类研究的职业，显然需要加强和扩大培训计划。每年出生的1000名婴儿中，至少有8名患有心脏缺陷--几乎占活产婴儿的1%。事实上，先天性心脏病是导致婴儿出生第一年死亡的主要原因。每年治疗这些婴儿的急性护理费用超过4亿美元。这一估计不包括诊所就诊、药物治疗和康复的慢性护理费用。 该计划将目前为期三年的奖学金培训计划扩大到四年，增加了一个研究年--无论是临床研究还是基础科学研究。此外，它通过为学员提供广泛的额外杜克研究资源，从而提供潜在的导师，从而加强了当前的杜克研究。这类资源的例子包括杜克临床研究所、基因组技术中心和人类遗传学中心。 该项目的总体指导将由著名的 儿科心脏病专家和该培训项目的项目主任。多学科临床研究培训计划旨在为年轻的临床科学家提供进行创新临床研究、翻译和测试临床领域的基础科学发现所需的工具和技能。通过在该项目中接受培训的临床研究人员的努力，实现改进的治疗方法是最终目标。基础科学研究培训计划旨在为年轻研究人员提供所需的知识和技能，以进行尖端科学研究，并在竞争激烈的学术儿科研究环境中取得成功。此外，该计划最重要的目标之一是确保年轻医生能够为患者的利益将研究成果转化为临床实践。

DESCRIPTION (provided by applicant): The overall goal of the proposed fellowship pediatric cardiololgy (sp) training grant program is to develop pediatric fellows into well-trained investigators with the potential to assume leadership roles in the nation's congenital heart disease research agenda. Through this two-year training program they will acquire the ability to perform exceptional clinical and basic science research into the causes, pathological mechanisms, and outcomes of congenital heart disease. Few Pediatric Cardiologists are trained to conduct research and comparatively few pediatric fellowship graduates have careers successfully performing such research, and the need to intensify and expand training programs is clear. At least eight of every 1,000 infants born each year have a heart defect - almost one percent of live-born infants. In fact, congenital heart disease is a leading cause of death during the first year of life. The acute care cost of treating these infants each year, exceeds $400,000,000. This estimate does not include the chronic care costs of clinic visits, medications, and rehabilitation. The program expands the current three-year fellowship training program to four years by adding an additional research year -- either in clinical or basic science research. Furthermore, it enhances the current one by offering trainees access to a wide range of additional Duke research resources and, thus, potential mentors. Examples of such resources include the Duke Clinical Research Institute, the Center for Genome Technology, and the Center for Human Genetics. The overall direction of this program will be provided by Dr. Stephen P. Sanders, a renowned pediatric cardiologist and Program Director of this training program. The multidisciplinary clinical research training program is designed to provide young clinical scientists with the tools and skills needed to perform innovative clinical research, translating and testing basic science discoveries in the clinical arena. Improved therapeutics, realized through the efforts of clinical investigators trained in this program, is the ultimate goal. The basic science research training program is designed to give young investigators the knowledge and skills needed to perform cutting-edge scientific research and succeed in the highly competitive research environment of academic pediatrics. Moreover, one of the most significant goals of the program is to ensure that young physicians will be able to translate, for the benefit of patients, research findings into clinical practice.