MESENCHYMAL STEM CELLS AND THE HEART

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 间充质干细胞(MSC)可能成为心脏修复的有用细胞。要做到这一点，必须阐明转分化的机制。我们将需要进行临床前研究。要做到这一点，我们必须建立成像能力，以识别DS红色转基因细胞(使用Duke光学系统)和Feridex标记细胞(MR显微镜)。第一步是检查培养中的细胞，以确定现有仪器的灵敏度；细胞培养将在北卡罗来纳大学教堂山进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mesenchymal stem cells (MSC) may become useful in repair of the heart. For this to occur, the mechanisms through which transdifferentiation must be elucidated. We will need to perform pre-clinical studies. To do this we must establish the ability of imaging to identify DS red transfected cells (with the Duke optical system) and Feridex labeled cells with (MR microscopy). The first step is to examine the cells in culture to determine the sensitivity of the available instruments; the cell culture will be done at UNC-Chapel Hill.