MESENCHYMAL STEM CELLS AND THE HEART

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 间充质干细胞（MSC）可能在心脏修复中变得有用。 要做到这一点，必须阐明转分化的机制。 我们需要进行临床前研究。 要做到这一点，我们必须建立成像能力，以识别DS红转染细胞（杜克光学系统）和菲立磁标记细胞（MR显微镜）。 第一步是检查培养物中的细胞，以确定可用仪器的灵敏度;细胞培养将在UNC-Chapel Hill进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mesenchymal stem cells (MSC) may become useful in repair of the heart. For this to occur, the mechanisms through which transdifferentiation must be elucidated. We will need to perform pre-clinical studies. To do this we must establish the ability of imaging to identify DS red transfected cells (with the Duke optical system) and Feridex labeled cells with (MR microscopy). The first step is to examine the cells in culture to determine the sensitivity of the available instruments; the cell culture will be done at UNC-Chapel Hill.