VASCULAR, PULMONARY AND RENAL INJURY

描述(由申请人提供)： Ruth L.Kirschstein机构国家研究服务奖(T32)的竞争延续申请侧重于医学博士、医学博士和博士候选人的博士后培训，为他们作为成功的临床医生科学家和/或生物医学研究科学家追求独立职业做准备，这些科学家的主要兴趣是人类疾病的细胞和分子机制。它的主要培训目标是通过非正式和结构化的教学练习发展核心研究能力，并在培育和支持学术医学中心的环境中提供深入的指导研究经验。计划的重点是通过应用现代细胞和分子生物学、免疫学、遗传学和基因组学、综合生理学和生物信息学的多学科研究工具和战略，了解影响心血管、肺、造血和免疫系统的主要疾病过程的基本致病机制。 目前的培训计划由国家心肺和血液研究所赞助，自1958年以来一直存在，总部设在哈佛医学院(HMS)的主要教学附属机构布里格姆妇女医院的病理科。虽然培训计划的核心教师主要是病理学系的临床科学家和基础生物医学研究人员，但学员也被鼓励利用朗伍德医学领域的研究导师/实验室提供的广泛机会，包括HMS基础科学系(如病理学、细胞生物学、系统生物学)、达纳-法伯癌症中心、贝丝-以色列女执事医学中心、哈佛-合作伙伴人类遗传学和基因组学中心，以及哈佛-麻省理工学院健康科学与技术计划。学员是从国家申请者库中挑选出来的，该计划的重点是根据给定候选人的背景、科学兴趣和职业目标量身定做的研究培训经验。

DESCRIPTION (provided by applicant): This Competing Continuation Application for a Ruth L. Kirschstein Institutional National Research Service Award (T32) is focused on the postdoctoral training of M.D., M.D.-Ph.D., and Ph.D. candidates to prepare them to pursue independent careers as successful Clinician-Scientists and/or Biomedical Research Scientists, whose primary interest is the cellular and molecular mechanisms of human disease. Its primary training goal is the development of core research competencies through both informal and structured didactic exercises, coupled with an indepth mentored research experience, in a nurturing and supportive academic medical center environment. The programmatic emphasis is on understanding the basic pathogenetic mechanisms underlying major disease processes that affect the cardiovascular, pulmonary, hematopoietic and immune systems, through the application of the multidisciplinary research tools and strategies of modern cellular and molecular biology, immunology, genetics and genomics, integrative physiology and bioinformatics. The current Training Program, sponsored by the National Heart, Lung and Blood Institute, has been in continuous existence since 1958, and is based in the Department of Pathology at the Brigham and Women's Hospital, a primary teaching affiliate of Harvard Medical School (HMS). While the Training Program's Core Faculty is comprised primarily of clinician-scientists and basic biomedical researchers in the Department of Pathology, trainees also, are encouraged to avail themselves of a wide spectrum of opportunities afforded by research mentors/laboratories in the Longwood Medical Area, including HMS basic science departments (e.g., Pathology, Cell Biology, Systems Biology), the Dana-Farber Cancer Center, the Beth Israel-Deaconess Medical Center, the Harvard-Partners Center for Human Genetics and Genomics, and the Harvard-MIT Health Sciences and Technology Program. Trainees are selected from a national pool of applicants, and the Program's emphasis is on a research training experience tailored to a given candidate's background, scientific interests and career goals.