Molecular Pathogenesis of Infectious Diseases

描述（由申请人提供）：本申请是我们在科罗拉多大学医学院的传染病分子发病机制博士前培训计划的第一次竞争性更新。这一新兴研究领域包括微生物毒力因子的分子生物学和生化研究、宿主抗性机制、感染期间基因表达的调节、在感染中发挥关键作用的微生物和宿主细胞分子的结构-功能分析、细菌和病毒的相互作用分析体外分化的宿主细胞，以及使用野生型或转基因微生物菌株和宿主动物在动物模型中进行细菌和病毒感染的研究。我们的培训教师的高度互动的成员已经证明了在这些领域的创新研究的生产力，成功的研究资金从美国国立卫生研究院和其他授予机构，并在培训博士前的学生在多学科方法所需的尖端研究传染病的发病机制的丰富经验。除了执行他们的指导研究项目，我们的学员将参加教学课程，研讨会，期刊俱乐部和研究进展会议的综合计划，这将训练他们识别重要的新研究问题，设计良好的控制实验使用各种各样的分子，细胞和体内技术，批判性地评估和展示他们的结果，理解并将道德原则应用于他们的研究。只有在学生完成所有必修课程，通过初步和综合考试并开始论文研究后，才能选择任命此培训计划。我们的综合，跨部门培训计划的广度将为学生在学术界或生物技术创新的职业生涯做好准备。这个充满活力的新培训计划非常成功。它促进了新的研究合作和赠款，改进了课程，并促进了博士前学员之间的跨学科互动。在4年以来，我们的传染病的分子发病机制的培训计划开始，我们的培训教师从19增加到21，并在教师实验室博士前学员的稳定状态从21增长到31。目前，这项培训补助金每年只为3名受训人员提供一年的支助。我们要求06-07年的4个职位为每年任命的3名学员中的1名提供2年的承诺，并要求08-10年的5个职位为另外一名学员提供资金，该学员的研究重点是与生物防御或新兴传染病病原体相关的感染分子机制。

DESCRIPTION (provided by applicant): This application is for the first competing renewal of our pre-doctoral training program on The Molecular Pathogenesis of Infectious Diseases at the University of Colorado School of Medicine. This emerging area of research encompasses molecular biological and biochemical studies on microbial virulence factors, host resistance mechanisms, regulation of gene expression during infection, structure-function analysis of microbial and host cell molecules that play key roles in infections, analysis of interactions of bacteria and viruses with differentiated host cells in vitro, and studies on bacterial and viral infections in animal models using either wild type or genetically modified strains of microbes and host animals. The highly interactive members of our training faculty have proven productivity for innovative research in these areas, successful research funding from NIH and other granting agencies, and extensive experience in training pre-doctoral students in the multidisciplinary approaches needed for cutting edge research on the pathogenesis of infectious diseases. In addition to performing their mentored research projects, our trainees will participate in a comprehensive program of didactic courses, seminars, journal clubs, and research-in-progress meetings which will train them to identify important new research questions, design well-controlled experiments using a wide variety of molecular, cellular and in vivo techniques, critically evaluate and present their results, and understand and apply principles of ethics to their research. Students are selected for appointment to this training program only after they have completed all of their required courses, passed their preliminary and comprehensive examinations and begun their dissertation research. The breadth of our integrated, interdepartmental training program will prepare students for innovative careers in academia or biotechnology. This dynamic new training program has been extremely successful. It has fostered new research collaborations and grants, improved the curriculum, and fostered interdisciplinary interactions among the pre-doctoral trainees. In the 4 years since our training program on the Molecular Pathogenesis of Infectious Diseases began, our training faculty increased from 19 to 21, and the steady state number of predoctoral trainees in faculty labs grew from 21 to 31. Currently this training grant provides only one year of support for 3 trainees each year. We request 4 positions in years 06-07 to provide a 2-year commitment for 1 of the 3 trainees appointed each year and 5 positions in years 08-10 to fund one additional trainee whose research will focus on molecular mechanisms of infection related to biodefense or emerging infectious disease agents.