Combined use of organo- and enzymic catalysis in three component couplings: Building blocks for bioactive molecule synthesis

生物分子的制备，如药物和农用化学品，通常涉及许多单独的合成步骤。在每一步结束时，中间体通常在下一步官能化之前被提纯。为了提高此类分子的构建效率，需要减少分离反应和提纯的次数。这项提议将产生新的方法，允许在一个反应容器中执行一个以上的步骤。这种方法广泛地类似于将涉及几个步骤的串联自然：代谢途径涉及在单个反应容器(细胞)中由兼容的(酶)催化剂处理反应中间体。新方法的产品将被用于合成用于制备生物活性分子的积木。

The preparation of biological molecules, such as drugs and agrochemicals, generally involves many separate synthetic steps. At the end of each step, an intermediate is usually purified before functionalisation in the next step. To improve the efficiency of the construction of such molecules, the number of separate reactions and purifications would need to be reduced. This proposal will generate new methods which will allow more than one step to be performed in a single reaction vessel. This approach is broadly analogous to would involve the concatenation of several steps Nature: metabolic pathways involve the processing of reaction intermediate by compatible (enzyme) catalysts in a single reaction vessel (the cell). The products of the new methodology will be exploited in the synthesis of building blocks for preparation of biologically active molecules.