Core Center for Quantitative Neuroscience with magnetic Resonance (QNMR)

磁共振（MR）技术在生命科学研究中的应用正在迅速增长。 最先进的异源MR波谱（MRS）和多模态MR成像（MRI）方法 在耶鲁大学磁共振研究中心（MRRC）培养的动物已经在体内移动 研究在实验神经科学中的核心作用，解决具有深远意义的基本问题 影响大脑功能自1980年代初耶鲁大学MRRC成立以来， 用于体内研究的水平孔磁体在2004年增加了三倍。目前的“ 需要用于体内研究的磁铁--动物和人类各三块--来匹配不断增长的 许多学科的研究人员-其中大多数得到NINDS的支持。的 耶鲁MRRC的优势一直是，现在仍然是，啮齿动物和人类之间的动态互动 research.在啮齿类动物中异源MRS和多模态MRI方法之间的积极相互作用， 人类进步更快。因为MR技术需要坚定不移的基础设施 支持国家的最先进的利用成功地应用，长期稳定的耶鲁MRRC是 这取决于持续的支持。磁共振定量神经科学 （QNMR）”耶鲁大学将支持NINDS资助的耶鲁大学研究人员使用的共享资源和设施， 从而产生比通过独立努力可能产生的更大的生产力。QNMR将包括 三个研究核心-每一个都致力于提高基于多模式的正在进行的研究的有效性， MRI、异源MRS、神经生理学和一个服务核心-专为快速数据而设计 使用高性能工作站集群进行分析、访问、共享和备份。我们预计 QNMR将为神经科学家提供一个更加合作和互动的研究环境， 利用MR技术在耶鲁大学，并将培育新的跨学科的方法在医学，生理学， 和神经科学

Applications of magnetic resonance (MR) techniques to research in the life sciences are growing rapidly. State-of-the-art heteronuclear MR spectroscopy (MRS) and multi-modal MR imaging (MRI) methodologies cultivated at the Magnetic Resonance Research Center (MRRC) at Yale have moved in vivo animal research into central roles in experimental neuroscience, addressing fundamental issues with far reaching implications for brain function. Since the formation of the Yale MRRC in the early in 1980s, the number of . horizontal-bore magnets for in vivo studies have multiplied three-fold in 2004. The present number of ' magnets for in vivo studies - three each for animals and humans - were needed to match the growing number of investigators across many disciplines - a majority of whom are supported by NINDS. The strength of the Yale MRRC has been, and still is, the dynamic interaction between rodent and human research. Active interplay between heteronuclear MRS and multi-modal MRI methods in rodents and humans have furthermore rapidly progressed. Because MR technology requires unwavering infrastructural support for state-of-the-art exploits to be successfully applied, long-term stability of Yale MRRC is contingent on sustained support. A program in "Quantitative Neuroscience with Magnetic Resonance (QNMR)" at Yale will support shared resources and facilities used by NINDS-funded investigators at Yale, and thereby generate greater productivity than would be possible via independent efforts. QNMR will consist of three research Cores - each dedicated to improving effectiveness of ongoing research based upon multimodal MRI, heteronuclear MRS, neurophysiology - and one service Core - designed for rapid data analysis, access, sharing, and backup using high-performance cluster of workstations. We expect that QNMR will promote a more cooperative and interactive research environment for neuroscientists who are utilizing MR technology at Yale, and will nurture new cross-disciplinary approaches in medicine, physiology, and neuroscience.