Core Facilities for Neurobiology at Brandeis

描述(由申请者提供)：我们要求建立三个核心设施，以支持NINDS资助的布兰迪斯大学的10个研究项目(调查人员：罗斯巴什、伯伦、格里菲斯、霍尔、利斯曼、马德、森古普塔、特里吉亚诺、韦尔特、怀特)。三个新的设施被提出：一个微阵列/流式细胞仪设备，一个转基因小鼠设备，和一个集成的多仪器成像设备。请拨资金购买每个设施的设备、人员和用品。每个设施都将有一个监督委员会，每个监督委员会的主席Sengupta、Birren和Turrigiano将与Rosbash一起组成指导委员会，监督整个设施的管理。这组由NINDS资助的研究人员在突触传递、神经调制、早期神经发育和突触形成的机制、行为遗传学以及神经功能的分子底物方面有着共同的兴趣。拟议中的新设施不会重复布兰迪斯大学校园内的任何现有设施，并且对于允许我们使用现在成为我们领域标准的新的最先进的方法来进行我们资助的研究是必不可少的。这些设施还将加强美国国立卫生研究院资助的布兰迪斯大学其他研究人员的研究。布兰迪斯大学对这些新设施作出了重大承诺，为空间和设备的翻新提供了资金。

DESCRIPTION (provided by applicant): We request funds to establish three core facilities to support 10 NINDS-funded research projects (investigators: Rosbash, Birren, Griffith, Hall, Lisman, Marder, Sengupta, Turrigiano, Welte, White) at Brandeis University. Three new facilities are proposed: A microarray/FACS facility, a transgenic mouse facility, and an integrated, multi-instrument imaging facility. Funds are requested for equipment, personnel, and supplies for each of the facilities. Each facility will have an oversight committee, and the chair of each of these oversight committees, Sengupta, Birren, and Turrigiano together with Rosbash, will constitute the Steering Committee to oversee the administration of the entire facility. This group of NINDS- funded investigators share common interests in the mechanisms of synaptic transmission neural modulation, early neural development and synapse formation, genetics of behavior, and the molecular substrates of neuronal function. The proposed new facilities do not duplicate any existing facilities on the Brandeis University campus and are essential to allow us to conduct our funded research employing the new state of the art methods now becoming standard in our field. These facilities will also enhance research by other NIH funded investigators at Brandeis University. Brandeis University has made a substantial commitment to these new facilities by providing funds for renovation of space and equipment.