2009 Biology of Aging Gordon Research Conference

描述（由申请人提供）：戈登研究会议自1931年以来一直是传播领先领域新的和未发表的想法的重要场所。2009年戈登老龄生物学研究会议，题为“衰老机制：关键效应器和合理的目标”将汇集来自老龄领域的研究人员与领导者在了解主要的年龄相关疾病，如糖尿病和癌症的生物学。老龄化领域已经到了一个可以认真讨论将科学进步转化为改善生活的临床或生活方式干预的潜力的时候了。近年来，炎症已成为年龄相关疾病的关键驱动因素，并将在整个会议中形成持续的主线。我们充分期待会议上的讨论和合作将有助于为老龄化领域确定方向，并加快干预措施的发展，以提高数百万人的生活质量。资金要求提供部分支持戈登研究会议（GRC）在生物学老化。2009年会议的主题将是“老龄化的机制：关键效应和理性目标”，将于2009年2月15日至19日在加州文图拉海滩的福朋喜来登酒店举行。珍妮特·M·洛德博士和大卫·辛克莱博士将组织这项科学计划。我们的目标是提供资金，以支持受邀演讲者，讨论领导者和初级科学家（博士后研究员，高级研究生，或新的，初级教师），他们将受益于会议并为会议做出贡献。我们邀请的演讲者在衰老的分子和细胞生物学，衰老的生理学和遗传学方面的研究得到国际认可。我们还特别强调了发言者谁可以有助于讨论炎症作为一个多效性效应器在衰老过程中，并在那些研究人员利用目前对衰老的理解，开发干预措施，以延长寿命和健康寿命。每个演讲者都是他们科学的强有力的传播者，可以激发热烈的讨论。老年医学目前面临的挑战是确定各种年龄相关的变化，在遗传和功能水平上，如何相互作用，导致体内平衡丧失，虚弱和病理。特别是，本次会议将考虑与年龄相关的促炎细胞因子的增加，所谓的“炎症”，作为主要器官系统衰老过程中的候选多效性效应子。因此，会议将包括关于神经退行性疾病和认知能力下降、心脏和肌肉骨骼系统老化、衰老在癌症中的作用以及免疫衰老的会议，每次会议都以炎症为主题。此外，很明显，老化过程的几个方面是有延展性的。近年来，已经描述了大量的遗传，药理学和饮食干预措施，可以减缓从单细胞生物到人类的系统衰老。因此，本GRC将包括健康老龄化干预措施的讨论。会议的目标是：（i）批判性地评估老龄化生物学的进展;（ii）利用老龄化生物学的知识来了解与年龄相关的衰退和社会的主要疾病;以及（iii）强调综合和转化研究成果，作为开发和验证可以延长人类健康寿命的新疗法的手段。

DESCRIPTION (provided by applicant): Gordon Research Conference have taken place since 1931 and have been a critical venue for the dissemination of new and unpublished ideas in leading fields. The 2009 Gordon Research Conference on The Biology of Aging, titled "Mechanisms of Aging: Key Effectors and Rational Targets" will bring together investigators from the aging field with leaders in understanding the biology of major age-related diseases such as diabetes and cancer. The aging field has reached a point in time where it can seriously discuss the potential of translating scientific progress into clinical or lifestyle interventions that improve lives. In recent years, inflammation has emerged as a key driver of age- related diseases, and will form a continuing thread throughout the conference. We fully anticipate that the discussions and the collaborations set up at the meeting will help set the directions for the field of aging and accelerate the development of interventions to improve quality of life for millions of individuals. Funds are requested to provide partial support for the Gordon Research Conference (GRC) in the Biology of Aging. The theme of the 2009 conference will be "Mechanisms of Aging: Key Effectors and Rational Targets" to be held at the Four Points Sheraton Hotel, Ventura Beach, California from February 15-19, 2009. Drs Janet M Lord and David Sinclair will organize the scientific program. Our aim is to provide funds to support invited speakers, discussion leaders, and junior scientists (postdoctoral fellows, advanced graduate students, or new, junior faculty), who would benefit from and contribute to the conference. The speakers we have invited are internationally recognized for their research on the molecular and cellular biology of aging, the physiology and genetics of aging. We have also placed particular emphasis upon speakers who can contribute to a discussion on inflammation as a pleiotropic effector in the aging process and upon those researchers utilizing current understanding of aging to develop interventions to extend longevity and healthspan. Each of the speakers is a strong communicator of their science who can stimulate lively discussions. The current challenge to biogerontology is to determine how the various age-related changes, at the genetic and functional level, interact to result in loss of homeostasis, frailty and pathology. In particular, this conference will consider the age-related increase in pro-inflammatory cytokines, so-called "Inflammaging", as a candidate pleiotropic effector in the aging process in major organ systems. The conference will thus include sessions on neurodegeneration and cognitive decline, aging of the heart and musculoskeletal systems, the role of aging in cancer, and immunosenescence, with inflammation as a topic running through each session. In addition, it has become clear that several aspects of the aging process are malleable. In recent years, a large number of genetic, pharmacological and dietary interventions have been described that slow down aging in systems ranging from unicellular organisms to humans. This GRC will thus include discussion of interventions for healthy aging. The goals of the conference are: (i) To critically assess progress in the biology of aging; (ii) To utilize knowledge about the biology of aging to understanding age-related decline and major disease of society; and (iii) to emphasize integrative and translational research findings as a means to develop and validate novel therapeutics that could extend human health span.