Protein Folding in the Cell

描述（由申请人提供）： 我们请求部分支持2008年，2010年和2012年美国实验生物学家协会（FASEB）夏季会议“细胞中的蛋白质折叠”。2008年会议将于2008年7月27日至8月1日在佛蒙特州的萨克顿河举行。这次非常成功的会议是独一无二的，它将细胞生物学家/遗传学家，生物化学家/生物化学家和数学建模者聚集在一起，以解决蛋白质折叠和错误折叠的复杂问题及其对人类疾病的影响。这次会议对该领域的发展至关重要，其重要程度怎么估计都不过分。历史上，研究蛋白质折叠的生物物理化学家和关注体内蛋白质生物发生的细胞生物学家没有广泛的相互作用;然而，生物学问题的复杂性需要理解机制以及细胞功能。现在，生物学家比以往任何时候都更接近机制，而理论家则在寻找与生物功能的联系。这是一个汇集了来自不同领域的前沿研究的会议，以允许思想的交叉施肥。这一会议的活力体现在以下事实上，即会议总是人满为患，不断有新的人希望参加会议。每次会议都保持我们的核心重点是蛋白质折叠的体内和体外机制，以及它们如何与细胞生物学，基因调控和人类疾病的基本过程相关，同时对新的发展给予相当大的关注。因此，在2008年，大约一半的计划涉及蛋白质折叠和执行此过程的分子机器的持久主题，以及由蛋白质错误折叠引起的疾病，另一半考虑单分子折叠的新主题，理解不同细胞区室和位置折叠的快速进展，以及新兴技术。通过这次会议，我们的目标是将物理和生物科学家聚集在一个互动的环境中，促进教育和对方法，实验限制的理解，并探讨共同利益。这次会议的规模小，环境孤立，所有与会者都在附近居住和用餐，促进了最佳的科学交流。会议形式将为非正式讨论提供广泛的场所。海报会议将允许所有参与者与其他研究人员进行科学互动。年轻的调查人员和妇女在发言者中占很大比例，我们鼓励他们参加会议，并提出了增加少数群体与会者人数的战略。

DESCRIPTION (provided by applicant): We request partial support for the 2008, 2010 and 2012 Federation of American Society of Experimental Biologists (FASEB) Summer Conference on "Protein Folding in the Cell". The 2008 meeting will be held July 27 to August 1, 2008 in Saxtons River, VT. This extraordinarily successful meeting is unique in bringing together cell biologists/geneticists, biophysicists/biochemists, and mathematical modelers to tackle the complex problems of protein folding and misfolding and their implications for human disease. The extent to which this meeting is central to the development of the field cannot be overestimated. Historically, biophysical chemists who study protein folding and cell biologists concerned with protein biogenesis in vivo have not interacted extensively; however the complexity of the biological problems requires understanding mechanism as well as cellular function. Now, more than ever, biologists are approaching mechanism while the theorists are seeking ties to biological function. This is the meeting that brings together cutting edge research from diverse fields to allow for cross-fertilization of ideas. The vitality of this meeting is attested to by the fact that it is always oversubscribed with a constant stream of new people wishing to join the meeting. Each meeting maintains our core focus on in vivo and in vitro mechanisms of protein folding and how they relate to basic processes in cell biology, gene regulation and human disease, while devoting considerable attention to new developments. Thus, in 2008 about half of the program deals with the enduring themes of protein folding and the molecular machines that carry out this process, as well as diseases resulting from protein misfolding and the other half considers the new themes of folding of single molecules, the rapid progress in understanding folding in different cellular compartments and locations, and emerging technologies. Our goal through this meeting is to bring together physical and biological scientists in an interactive environment, to promote education and understanding of the approaches, experimental limitations and to explore common interests. The small size and isolated setting of this meeting with all participants residing and taking their meals in close proximity promotes optimal scientific exchange. The conference format will provide extensive arenas for informal discussions. Poster sessions will allow all participants to interact scientifically with other investigators. Young investigators and women are well-represented among speakers and encouraged to attend the conference and we propose strategies to increase the number of minority participants.