Image-based Measures for Osteoarthritis

描述(申请人提供)：在20世纪80年代末，MRI卓越的软组织对比度应用于关节成像导致了极大的乐观情绪，这将有助于理解骨关节炎的自然历史，并将疗法应用于骨关节炎。然而，近20年后的今天，临床上仍有许多关于骨性关节炎的信息尚未被发现，治疗骨性关节炎的药物(DMOAD)还没有成功的临床试验，放射学仍是骨性骨性关节炎影像检查的主要手段。拟议研讨会的目标是将基础骨性关节炎研究人员、骨科医生和风湿科医生、成像科学家、仪器制造商以及制药和监管代表聚集在一起，阐明骨关节炎研究中的紧迫问题，成像科学迄今做出了哪些贡献，成像可以开始解决哪些问题，以及未来需要哪些资源和研究议程来实现这一目标。除了陈述和讲台讨论外，还将有两个海报会议，来自提交的摘要，旨在进一步阐明来自社区的紧迫问题。研讨会的召开正值办公自动化研究的关键时刻。骨性关节炎是一种临床疾病，目前的治疗主要是止痛药和全关节置换术。由于疾病进程反应迟缓的措施，开发减缓、阻止或逆转疾病进程的试剂的努力已经放缓。目前正在对办公自动化进行前所未有的投资(行业和联邦政府赞助)，目的是解决这一紧迫问题，并开发新的和反应灵敏的成像标记。然而，对于关节中的哪些结构要成像，如何成像这些结构，以及如何测量这些变化，几乎没有达成共识。拟议的会议将促进这一对话，既努力促进适当的标记发展，又在缺乏现有措施的情况下，为未来的研究议程提供建议。在此之前，2007年6月在奥地利萨尔茨堡举行的首届基于影像的骨关节炎测量年度研讨会非常成功，130名注册者参加了为期3天的研讨会，以启动这一亟需的对话。远期目标：促进骨性关节炎活体成像的应用研究和开发。具体的短期目标：为科学计划委员会和年轻研究人员出席2008年6月25日至28日在美国马萨诸塞州波士顿举行的第二届骨关节炎基于成像的措施年度研讨会提供旅费和会议登记的估计费用。拟议研讨会的目标是将基础骨性关节炎研究人员、骨科医生和风湿科医生、成像科学家、仪器制造商以及制药和监管代表聚集在一起，阐明骨关节炎研究中的紧迫问题，成像科学迄今做出了哪些贡献，成像可以开始解决哪些问题，以及未来需要哪些资源和研究议程来实现这一目标。

DESCRIPTION (provided by applicant): In the late 1980s, the application of the superb soft tissue contrast of MRI to image the joint led to great optimism that inroads to understanding the natural history of, and applying therapeutics to, osteoarthritis would be quickly forthcoming. However, nearly 20 years later, much about clinical OA has yet to be discovered, there is yet to be a successful trial for a disease modifying OA drug (DMOAD), and radiography is still the mainstay of imaging of OA. The goal of the proposed workshop is to bring together the communities of basic osteoarthritis researchers, orthopedists and rheumatologists, imaging scientists, instrument manufacturers, and pharmaceutical and regulatory representatives to delineate what the pressing questions are in OA research, what imaging science has contributed thus far, what questions imaging can start to address, and what resources and research agenda going forward are needed to accomplish this. In addition to the presentations and podium discussions, there will be two poster sessions from submitted abstracts meant to further elucidate the pressing questions from the community. The workshop comes at a critical time in OA research. OA is a clinical disease where the mainstay of current management is analgesic medication and total joint replacement. Efforts to develop agents to slow, halt or reverse the disease process have been slowed by unresponsive measures of the disease process. Unprecedented investment (both industry and federally sponsored) is currently underway in OA aimed at addressing this pressing concern and developing new and responsive imaging markers. However, there is little consensus on which structures in the joint to image, how to image these structures, and how to measure these changes. The proposed conference will facilitate this dialogue in an effort both to promote appropriate marker development, and in the absence of current measures, provide suggestions for future research agendas. It follows a highly successful 1st Annual Workshop on Imaging Based Measures of Osteoarthritis held in Salzburg, Austria in June 2007 where 130 registrants attended a 3 day workshop to initiate this much needed dialogue. Long Term Objective: To promote applied research and development to applications of in vivo imaging of osteoarthritis. Specific Short Term Objective: To provide funds for estimated costs for travel and meeting registration for scientific program committee and young investigators to attend the 2nd Annual Workshop on Imaging Based Measures on Osteoarthritis from June 25th to 28th 2008 in Boston, MA USA. The goal of the proposed workshop is to bring together the communities of basic osteoarthritis researchers, orthopedists and rheumatologists, imaging scientists, instrument manufacturers, and pharmaceutical and regulatory representatives to delineate what the pressing questions are in OA research, what imaging science has contributed thus far, what questions imaging can start to address, and what resources and research agenda going forward are needed to accomplish this.