Stereoselective Catalysis of the Asymmetric Desymmetrization of Meso Compounds

描述(由申请者提供)：向Fogarty国际研究合作奖提议，Houk教授(加州大学洛杉矶分校)和Aviyente教授(土耳其伊斯坦布尔Bogazici大学)就中观化合物去对称化的立体选择性催化进行建模。母项目(GM-36700)的目标是开发探索和预测立体选择性有机反应的计算方法，其标题为“合成有机反应的立体选择性”。FIRCA项目的具体目标是了解在中环酸酐的不对称脱对称反应中立体选择性非酶开环的起源。最终目标是从理论上理解控制立体选择性的因素，并预测这种类型的新的有用反应。

DESCRIPTION (provided by applicant): A collaboration between Professor Houk (UCLA) and Professor Aviyente (Bogazici University, Istanbul, Turkey) on modeling the stereoselective catalysis of the desymmetrization of meso compounds is proposed to the Fogarty International Research Collaboration Award. The goal of the parent project (GM-36700), entitled "Stereoselectivities of Synthetic Organic Reactions," is to develop computational methods to explore and predict stereoselective organic reactions. The specific aim of the FIRCA project, entitled "Stereoselective Catalysis of the Asymmetric Desymmetrization of Meso Compounds," is to understand the origins of the stereoselective nonenzymatic ring openings in the desymmetrization of meso cyclic anhydrides. The ultimate goal is to develop a theoretical understanding of the factors that control stereoselectivity and to predict new useful reactions of this type.