2008-2011Metals in Biology Gordon Research Conference and Associated Graduate Res

摘要：本提案要求为每年1月下旬在加州文图拉举行的戈登-凯南生物无机研究生研究研讨会（MIB GK-GRS）及其后续会议戈登-凯南生物无机金属研究会议（MIB GK-GRS）提供三年的部分支持。金属离子在超过三分之一的酶中起着关键作用，并参与许多与健康有关的重要生物合成途径，包括电化学向化学能的转化，以及抗生素、DNA、神经递质、类固醇、白三烯和激素的生物合成。关于金属酶功能的分子水平的细节出现在几个互补的研究线，在化学，生物学和物理学的界面。这些会议的广泛和长期目标是促进在一个高度跨学科的研究领域的讨论和合作，并通过为他们提供自己的社区意识来培养我们社区的年轻成员，并允许我们领域未来的领导者出现。该应用程序的意义在于，MIB GRC为生物无机化学前沿研究的讨论提供了主要论坛。本次会议的具体目标是在一个相对孤立的环境中召集27位代表金属离子在生物学研究中的关键领域的演讲者，总共有150名与会者参加为期五天的会议。该计划将有一个主题演讲和九个会议，广泛讨论当前的问题：质子耦合电子转移，铁硫簇作为电子传递剂和复杂多电子过程催化剂的组装和演变，硫配体在促进金属酶功能中的作用，金属离子促进0-0键的形成和裂解，氧化应激下形成的活性氧的检测和解毒。以及生物催化。此外，两次晚间海报会议将使所有与会者都能对这些主题的讨论作出贡献。金属离子在超过三分之一的酶中起着至关重要的作用，并参与了许多重要的生物合成途径，包括电化学向化学能的转化，以及抗生素、DNA、神经递质、类固醇、白三烯和激素的生物合成。关于金属酶功能的分子水平的细节出现在几个互补的研究线，在化学，生物学和物理学的界面。与MIB GRC会议相关的正式和非正式讨论对于该领域的进步和促进这一高度跨学科研究领域的合作至关重要。

DESCRIPTION (provided by applicant): Abstract: This proposal requests three years of partial support for the Metals in Biology Gordon Research Conference (MIB GRC) and its descendent, the Gordon-Kenan Bioinorganic Graduate Research Seminar (MIB GK-GRS), to be held annually in Ventura, CA in late January. Metal ions play critical roles in over one third of all enzymes, and are involved in a number of important health related biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. The molecular level details regarding metalloenzyme function emerge from several complementary lines of study, at the interface of chemistry, biology, and physics. The broad and long term goal of these conferences are to foster discussion and collaborations in a highly interdisciplinary area of research, and nurture the younger members of our community by providing them with their own sense of community, and allowing the future leaders of our field to emerge. The significance of this application is that the MIB GRC provides the principal forum for the discussion of research at the forefront of bioinorganic chemistry. The specific aims of this meeting will be to convene ~27 speakers that represent critical areas of metal ions in biology research with a total of 150 participants for a five day conference in a relatively isolated setting. The program will have a keynote address and nine sessions that broadly address current issues in proton-coupled electron transfer, the assembly and evolution of iron sulfur clusters as electron transport agents and catalysts for complex multi electron processes, the role played by sulfur ligands in promoting metalloenzyme function, metal ion-promoted 0-0 bond formation and cleavage, the detection and detoxification of reactive oxygen species formed under oxidative stress, and bioinspired catalysis. In addition, two evening poster sessions will permit all of the conferees to contribute to the discussion of these topics. Metal ions play critical roles in over one third of all enzymes, and are involved in a number of important biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. The molecular level details regarding metalloenzyme function emerge from several complementary lines of study, at the interface of chemistry, biology, and physics. Both the formal and informal discussions associated with the MIB GRC meeting are critical to the advancement of the field, and fostering collaborations in this highly interdisciplinary area of research.