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A PHASE I STUDY OF A COMBINATION OF YTTRIUM-90 LABELED HUMANIZED ANTI-CEA M5A

A PHASE I STUDY OF A COMBINATION OF YTTRIUM-90 LABELED HUMANIZED ANTI-CEA M5A
YTTRIUM-90 标记的人源化抗 CEA M5A 组合的 I 期研究
批准号：
7716670
负责人：
JEFFREY Y WONG
金额：
$2.28万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-04-20 至 2008-11-30
来源：
https://reporter.nih.gov/project-details/7716670
关键词：
90YAnti-CEA AntibodyAntibodiesComputer Retrieval of Information on Scientific Projects DatabaseFundingGrantInstitutionLabelMaximum Tolerated DosePhasePhase I Clinical TrialsRadioimmunoconjugateResearchResearch PersonnelResourcesSourceTherapeutic AgentsUnited States National Institutes of Healthchemotherapygemcitabine

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中文摘要
翻译
这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 I期试验将评估治疗剂Y-90-M5 A-人源化抗CEA抗体与吉西他滨化疗的组合。 其将定义放射性标记抗体与吉西他滨联合给药的最大耐受剂量。 此外，还将评估抗体的免疫原性。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A Phase I trial will evaluate the therapeutic agent Y-90-M5A-humanized anti-CEA antibody in combination with Gemcitabine chemotherapy. It will define the maximum tolerated dose of the radiolabeled antibody in combination with Gemcitabine. In addition, immunogenecity of the antibody will be assessed.
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