CLINICAL TRIAL: ACTG 362: EFFICACY OF AZITHROMYCIN PROPHYLAXIS FOR THE PRIMARY P

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 ACTG 362：这项研究的主要目的将是看看长期服用HAART方案(高效抗逆转录病毒疗法)是否会继续防止您感染艾滋病，定义为并发症和严重的细菌感染。长期服用艾滋病毒药物的一些患者血液中脂肪(胆固醇和甘油三酯)水平增加，可能与心脏病发作的风险增加有关。继续跟踪这项研究的第二个目的是确定参与研究的受试者中心脏病发作和中风的发生率。由于这项研究中的受试者已经服用HIV药物很长时间(大约一半已经服用阿奇霉素)，继续这项研究可能有助于确定服用阿奇霉素是否会对研究受试者中心脏病发作和中风的风险产生影响。这项研究的另一个目标是每年在研究中对受试者进行一次简短的记忆力和精神集中测试，以确保抗艾滋病毒药物保护大脑免受艾滋病毒的损害。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ACTG 362: The main purpose of this study will be to see if taking a HAART regimen (highly active antiretroviral therapy) for a long period of time will continue to prevent you from getting AIDS defining complications and serious bacterial infections. Increased levels of fats (cholesterol and triglycerides) in the blood have been seen in some patients taking HIV drugs for a long time, and may be linked to possible increased risk of heart attacks. A secondary purpose of continuing to be followed on this study will be to determine the rates of heart attacks and strokes among subjects enrolled in the study. Because the subjects in this study have been on HIV medication (and about half have been on azithromycin) for a long time, continuing the study may help to determine if having taken azithromycin will have an effect on the risk of heart attacks and strokes among the study subjects. An additional goal of the study is to briefly test the subjects memory and mental concentration once each year while they are in the study to be sure that the anti-HIV drugs are protecting the brain from damage by HIV.