CLINICAL TRIAL: SESAME OIL CONSUMPTION ON CARDIOVASCULAR RISK FACTORS IN HEALTHY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 我们最近的动物研究表明，芝麻油给动脉粥样硬化小鼠的管理显着降低血脂，炎症标志物，和整体减少动脉粥样硬化的过程。芝麻油是一种无毒的食用油，富含单不饱和脂肪酸和多不饱和脂肪酸，此外还含有木脂素和抗氧化（非皂化）成分。 许多健康益处都归功于石油。 虽然，药理学试剂可用于降低血清脂质，但它们昂贵并且长期使用具有副作用。 因此，有必要描述芝麻油是否对人类动脉粥样硬化标志物有有益的影响。 这项研究将确定补充芝麻油是否会提供心血管益处，通过脂质/脂蛋白水平，葡萄糖稳态，炎症和氧化生物标志物的变化来衡量，超出了在具有类似脂肪酸组成的油中所看到的。 这项研究将使用正常受试者，并应提供有价值的见解的潜在重要性的非皂化成分的芝麻油。 我们提出以下具体目标，以确定食用芝麻油的有效性和安全性： 1)确定芝麻油对正常健康受试者心血管风险标志物的影响。 具体来说，我们将确定补充芝麻油后对血脂脂蛋白谱、血压、葡萄糖稳态、炎症和氧化应激生物标志物的任何影响。 2)通过将上述结果与食用类似脂肪酸组成的油混合物的正常健康受试者的终点进行比较，确定芝麻油的非皂化成分是否调节心血管风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our recent animal studies have demonstrated that administration of sesame oil to atherosclerotic mice dramatically reduced serum lipids, inflammatory markers, and overall decreased atherosclerotic process. Sesame oil is a non-toxic edible oil, which is rich in both mono-unsaturated and poly-unsaturated fatty acids, plus it contains lignans and antioxidant (non-saponifiable) components. Numerous health benefits have been attributed to the oil. Although, pharmacological agents are available for the reduction of serum lipids, they are expensive and have side effects with prolonged use. Therefore, it is essential to describe whether sesame oil would have beneficial effects on markers of atherosclerosis in humans. This study will determine whether supplementation with sesame oil will provide cardiovascular benefits as measured by changes in lipid/lipoprotein levels, glucose homeostasis, inflammatory and oxidative biomarkers, beyond what is seen in oil with analogous fatty acid composition. The study will use normal subjects and should provide valuable insights into the potential importance of non-saponifiable components of sesame oil. We propose the following specific aims to determine the efficacy and safety of sesame oil consumption: 1) To determine the effect of sesame oil on markers of cardiovascular risk in normal, healthy subjects. Specifically, we will determine any effect, after sesame oil supplementation, on the lipid lipoprotein profile, blood pressure, glucose homeostasis, inflammatory and oxidative stress biomarkers. 2) To determine whether the non-saponifiable components of sesame oil are modulating cardiovascular risk by comparing above mentioned results with the endpoints from normal, healthy subjects who consume an oil mixture of analogous fatty acid composition.