EFFECTS OF RACE/ETHNICITY ON ADIPONECTIN LEVELS AND INSULIN ACTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 2型糖尿病(T2 DM)及其长期并发症在非裔美国人中比在美国白人中更常见(1，2)。葡萄糖/胰岛素代谢和胰岛素敏感性的种族差异的发病机制尚不清楚。尽管对糖耐量减低(IGT)和T2 DM的发病机制的了解有了很大的进步和进步，但对T2 DM起关键作用的β细胞功能障碍和胰岛素抵抗的机制仍然不确定。越来越多的证据表明，促炎性脂肪细胞因子可能介导了导致T2 DM和心血管疾病(CVD)的某些代谢紊乱(3-28)。其中，脂联素受到了更大的关注。脂联素已被证明可以预测未来的2型糖尿病、高血压和冠状动脉疾病(3-5，10)。本项目将探索脂联素在健康的非裔美国人(AA)和白人美国人(WA)的葡萄糖稳态、胰岛素作用和代谢以及底物氧化中的不同作用。这项研究还将确定循环中的三聚体、异源三聚体、六聚体等在非裔美国人和白人美国人中是否有所不同。健康的AA和WA将被招募参与这项研究。收集的信息将包括相关的血液样本、人体测量、身体成分的DEXA扫描、评估内脏肥胖的腹部CT、评估胰岛素敏感性的正常血糖-同位素钳以及评估静息能量消耗的间接量热法。人们希望这个项目将有助于显示种族如何在葡萄糖/胰岛素代谢和胰岛素敏感性中发挥作用，以及脂联素如何与这些因素相关。内源性脂联素水平的刺激有望为未来预防和管理非裔美国人的2型糖尿病和心血管危险因素提供一种新的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 2 diabetes (T2DM) and its long-term complications are more prevalent in African Americans than in White Americans (1,2). The pathogenesis of the racial differences in glucose/insulin metabolism and insulin sensitivity remains uncertain. Despite the enormous progress and advancements in understanding the pathogenetic basis of impaired glucose tolerance (IGT) and T2DM, the mechanisms for beta cell dysfunction and insulin resistance that are pivotal for T2DM remain uncertain. There is increasing evidence to indicate that proinflammatory adipocytokines could mediate some of the metabolic derangements leading to T2DM and cardiovascular diseases (CVD) (3-28). Among them, Adiponectin has received greater attention. Adiponectin has been shown to predict future type 2 diabetes, hypertension and coronary artery disease (3-5, 10). The present project will explore the differential role of adiponectin in glucose homeostasis, insulin action and metabolism and substrate oxidation in healthy African Americans (AA) and White Americans (WA). The study will also identify whether the circulating trimers, heterotrimers, hexatrimers etc. are different in African Americans and White Americans. Healthy AA and WA will be recruited to participate in the study. Information collected will include related blood samples, anthropometric measurements, DEXA scan for body composition, abdominal CT to evaluate visceral adiposity, euglycemic-isotope clamp to assess insulin sensitivity and indirect calorimetry to assess resting energy expenditure. It is hopeful that this project will help show how ethnicity plays a role in glucose/insulin metabolism and insulin sensitivity and how adiponectin relates to theses factors. It is hopeful that the stimulation of endogenous adiponectin levels could provide a novel approach for the future prevention and management of type 2 diabetes and perhaps cardiovascular risk factors in African Americans.