ENDOCRINE EVALUATION OF PANCREATIC TRANSPLANT

胰腺移植的内分泌评估

• 批准号: 6303104
• 负责人: KWAME none OSEI
• 金额: $ 4.86万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6303104
• 关键词: biomarker; clinical research; glucose metabolism; human subject; human therapy evaluation; insulin; insulin dependent diabetes mellitus; longitudinal human study; pancreas transplantation; transplant rejection

Type I diabetics undergoing pancreatic transplantation surgery are studied pre- and immediately post-surgery. Long-term follow up includes these assessments: (1) study of the impact of physiologic regulation of glucose insulin kinetics and metabolic control, (2) study to provide data on endocrine markers to identify early rejection of the transplanted pancreas, (3) study of the endocrine responses to various stimulatory tests on denervated, systematically drained, pancreas preparation.

在手术前和手术后立即研究接受胰腺移植手术的I型糖尿病患者。长期随访包括以下评估：（1）研究葡萄糖胰岛素动力学和代谢控制的生理调节的影响，（2）研究提供内分泌标志物的数据，以识别移植胰腺的早期排斥反应，（3）研究对去神经、系统引流的胰腺准备的各种刺激试验的内分泌反应。