Perfectionism in adolescents with depression

描述（由申请人提供）：青少年抑郁症治疗研究（TADS）是一项由国家精神卫生研究所资助的随机对照试验，在14个地点进行。439名年龄在12到17岁之间，被诊断为重度抑郁症的青少年参加了TADS。参与者被随机分配到四种治疗中的一种：认知行为疗法（CBT）、氟西汀（FIX）、认知行为疗法联合氟西汀（Combo）或药丸安慰剂（PBO）。除了主要的结果测量外，TADS数据集中还包括了一些额外的测量，这些测量将用于二次分析。我的研究将着眼于功能失调的态度在青少年抑郁症发展中的作用。具体来说，我将探讨完美主义作为抑郁症状和自杀的治疗反应的可能预测者、调节者和/或中介。纵向数据将在大约一年内提供，并将允许测试完美主义，功能失调态度和抑郁之间关系的模型。这些发现将有助于理解抑郁症的认知易感性和青少年抑郁症的治疗反应机制。

DESCRIPTION (provided by applicant): The Treatment for Adolescents with Depression Study (TADS) is a randomized controlled trial funded by the National Institute of Mental Health and conducted at 14 sites. A sample of 439 adolescents between 12 and 17 years of age with a diagnosis of major depressive disorder participated in TADS. Participants were randomly assigned to 1 of 4 treatments: cognitive behavior therapy (CBT), fluoxetine (FIX), cognitive behavior therapy in combination with fluoxetine (Combo), or pill placebo (PBO). In addition to primary outcome measures, several additional measures were included in the TADS dataset and will be available for secondary analyses. My research will look at the role of dysfunctional attitudes in the development of adolescent depression. Specifically, I will explore perfectionism as a possible predictor, moderator, and/or mediator of treatment response in terms of depression symptoms and suicidality. Longitudinal data will be available in approximately 1 year and will allow for the testing of models of relations between perfectionism, dysfunctional attitudes, and depression. These findings will contribute to the understanding of cognitive vulnerability for depression and mechanisms of treatment response in depressed adolescents.