Lightweight Ambient Pressure & Temperature Oxygen Concentrator (LAPTOC)

描述（由申请人提供）：该II期项目的目标是为COPD患者提供负担得起且不显眼的便携式供氧设备。长期供氧治疗（LTOT）——持续供氧与运动相结合——显著提高了这些患者的生存率。开发一种安全的电池供电设备，不会干扰正常的日常活动，将促进患者对治疗的依从性，提高他们的生活质量。该研究项目支持NHLBI的使命，即指导与肺部疾病患者的治疗和康复有关的设备的开发研究。正在开发的便携式氧气浓缩器重量将不到1.5公斤，但将提供所需的每分钟2-3升（Lpm）当量氧气流量，持续6小时。与现有的便携式集中器相比，这种显著的性能改进将通过重新设计集中器架构来实现。三维原型将用于创建能量存储、动力传输和惯性阻尼组件，这些组件共享功能，从而减少设备质量。SDGroup和其他公司正在开发的快速动力学空气分离吸附剂将实现专有的快速循环，能量回收设计的应用，将功耗降低到15W/Lpm输送氧气。将开发自适应功率控制算法来协调传感器输入、患者数据和保护功能。患者数据日志将集成到设备中，允许呼吸临床医生确认依从性和个性化治疗。慢性阻塞性肺疾病（COPD）折磨着美国超过1250万人，是第四大死因。运动结合持续氧疗已被证明是治疗这种疾病最有效的方法。该项目将开发一种非常紧凑、轻便和安静的便携式氧气浓缩器，以增强患者的依从性，并改善需要长期氧气治疗（LTOT）的低氧性COPD患者的生活质量。

DESCRIPTION (provided by applicant): The objective of this Phase II project is to provide an affordable and unobtrusive portable oxygen supply for COPD patients. Long term oxygen therapy (LTOT)-continuous oxygen combined with exercise-dramatically increases survival rates for these patients. Development of a safe battery operated device that does not interfere with normal daily activities will promote patient compliance with therapy and enhance their quality of life. This research project supports the NHLBI's mission to direct research in the development of devices related to the treatment and rehabilitation of patients suffering from lung disease. The portable oxygen concentrator under development will weigh less than 1.5 kg, yet will deliver the required 2-3 liters per minute (Lpm) equivalent oxygen flow for a period of 6 hours. This dramatic performance improvement over existing portable concentrators will be achieved by re-engineering the concentrator architecture. Three dimensional prototyping will be used to create energy storage, power transmission, and inertial damping components that share functionalities and thus reduce device mass. Fast kinetics air separation adsorbents being developed as SDGroup and elsewhere will enable the application of a proprietary rapid cycle, energy recuperative design that reduces power consumption to 15W/Lpm delivered oxygen. Adaptive power control algorithms will be developed to coordinate sensor input, patient data, and conserver functions. A patient data log will be integrated into the device, allowing the respiratory clinician to confirm compliance and personalize therapy. Chronic Obstructive Pulmonary Disease (COPD) afflicts over 12.5 million people in US and is the fourth leading cause of death. Exercise combined with continuous oxygen therapy has been shown to be the most effective treatment for this disease. This project will develop an extremely compact, lightweight and quiet portable oxygen concentrator that will augment patient compliance and improve quality of life for hypoxemic COPD patients requiring long term oxygen therapy (LTOT).