Host cell death signaling and susceptibility to bacterial gut infection

细菌感染是世界范围内传染病的主要原因。在这里，我们的目标是描述有助于对抗大肠杆菌和沙门氏菌感染的免疫反应。这些细菌已经进化出方法，在感染期间关闭我们的许多免疫反应，使它们能够存活并引发疾病。这项工作将有助于了解肠道细菌与我们的免疫系统之间的复杂关系，并为控制感染和治疗肠道免疫疾病提供解决方案。

Bacterial infections are a major cause of infectious disease worldwide. Here we aim to characterise immune responses that help fight infection by E. coli and Salmonella. These bacteria have evolved ways to shut down many of our immune responses during infection, allowing them to survive and cause disease. This work will help understand the complex relationship between gut bacteria and our immune system and provide solutions for controlling infection and treating immune disorders of the gut.