Alkynes as Masked Ylides. A Concept for New Reactions and Reactivity

叶立德是一种非常有用的试剂，具有不同的反应性，用于合成小分子和大分子、简单分子和复杂分子。然而，由于叶立德是敏感物种，它们只能在使用前立即被引入分子中。它们的合成前体也是高活性物种，不能通过其他操作进行。因此，尽管叶立德反应本身可能非常有效，但将它们引入分子所需的漫长、低效、僵化和不宽容的策略降低了它们的潜在适用性。同样，使用它们的任何合成的经济和效率都会受到不利的影响。在这项拟议的研究中，一种新的催化过程将允许原位制备叶立德，其强大的官能团可以毫发无损地进行各种转化。访问一系列不同的YLID的灵活战略，加上它们随后的反应，将导致一系列不同的新转变。这种新方法将通过利用叶立德化学的力量进行更经济的合成，同时绕过冗长和无效的起始材料准备。由此产生的合成策略将比目前更短、更有效，消耗的化学和时间资源更少，产生的废物也更少。

Ylides are very useful reagents with a diverse range of reactivity, employed in the synthesis of small and large, simple and complex molecules. However, as ylides are sensitive species they can be introduced into a molecule only immediately prior to their use. Their synthetic precursors are also highly reactive species which cannot be carried through other manipulations.So whilst the ylide reactions themselves can be very effective, the long, inefficient, inflexible and intolerant strategies required to introduce them into a molecule, reduces their potential applicability. Similarly, the economy and efficiency of any synthesis that employs them is adversely affected.In this proposed research, a novel catalytic process will allow ylides to be prepared in situ, from robust functionality which can be carried through a variety of transformations unscathed. The flexible strategy to access a range of different ylides, coupled with their subsequent reactions will lead to a diverse array of new transformations. This new approach will result in more economical synthesis by utilising the power of ylide chemistry, whilst bypassing lengthy and inefficent starting material preparations. The resulting synthetic strategies will be shorter and more efficient than at present, with less chemical and time resource consumed and less waste produced.