Physical Activity Dependent Plasticity CNS Sympathetic Nervous System Regulation

描述（由申请人提供）：久坐不动的生活方式是心血管疾病的主要危险因素，心血管疾病是美国死亡的主要原因。与缺乏运动有关的心血管疾病与交感神经系统的过度活动有关。申请人的长期目标是了解久坐不动的生活方式导致心血管疾病发病率增加的机制。目前这项研究的目的是验证这样一种假设，即不运动和运动对脑干中特定神经元群的结构和功能产生不同的改变，这些神经元群对血压调节至关重要。为了实现这一建议的目标，PI在密苏里大学和澳大利亚弗林德斯研究所组建了一个专家小组。我们期望在这个为期两年的项目结束时确定身体活动和不活动对延髓吻侧腹外侧脊髓投射神经元的结构和功能的调节程度。强有力的初步数据和先前发表的数据支持这些具有挑衅性和独特的假设。这一建议的结果将提供对久坐不动的生活方式对心血管健康的有害影响的更好理解，并确定治疗和预防心血管疾病的潜在治疗靶点。

DESCRIPTION (provided by applicant): A sedentary lifestyle is a major risk factor for cardiovascular disease, the leading cause of death in the United States. Cardiovascular diseases related to physical inactivity are associated with overactivity of the sympathetic nervous system. The long term goal of the applicant is to understand the mechanisms by which a sedentary lifestyle contributes to the increased incidence of cardiovascular disease. The objective of the current proposal is to test the hypothesis that physical inactivity versus physical activity produces differential alterations in the structure and function of a specific population of neurons in the brainstem that are critical for blood pressure regulation. In order to achieve the objectives of this proposal, the PI has assembled an expert team at the University of Missouri and the Flinders Institute in Australia. We expect to establish at the end of this two year project the extent to which physical activity and inactivity regulates the structure and function of spinally projecting neurons in the rostral ventrolateral medulla. Strong preliminary data and previously published data support these provocative and unique hypotheses. The results of this proposal will provide a greater understanding of the detrimental effects of a sedentary lifestyle on cardiovascular health and define potential therapeutic targets for the treatment and prevention of cardiovascular diseases.